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Titolo:
Cardiac I-123-MIBG uptake in idiopathic ventricular tachycardia and fibrillation
Autore:
Schafers, M; Wichter, T; Lerch, H; Matheja, P; Kuwert, T; Schafers, K; Borggrefe, M; Breithardt, G; Schober, O;
Indirizzi:
Univ Munster, Dept Nucl Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Nucl Med, D-48129 Munster, Germany Univ Munster, Dept Cardiol, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 t Cardiol, D-48129 Munster, Germany Univ Munster, Dept Angiol, D-48129 Munster, Germany Univ Munster MunsterGermany D-48129 pt Angiol, D-48129 Munster, Germany Univ Munster, Inst Arteriosclerosis Res, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 rosis Res, D-48129 Munster, Germany
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 40, anno: 1999,
pagine: 1 - 5
SICI:
0161-5505(199901)40:1<1:CIUIIV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL SYMPATHETIC DYSINNERVATION; POSITRON EMISSION TOMOGRAPHY; LONG QT SYNDROME; METAIODOBENZYLGUANIDINE METAIODOBENZYLGUANIDINE; HEART; CARDIOMYOPATHY; INNERVATION; DISEASE; NOREPINEPHRINE; SCINTIGRAPHY;
Keywords:
cardiac sympathetic innervation; idiopathic ventricular tachycardia; idiopathic ventricular fibrillation; I-123-metaiodobenzylguanidine SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schafers, M Univmanyster, Dept Nucl Med, Albert Schweitzer Str 33, D-48129Munster, Ger Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
M. Schafers et al., "Cardiac I-123-MIBG uptake in idiopathic ventricular tachycardia and fibrillation", J NUCL MED, 40(1), 1999, pp. 1-5

Abstract

Patients with idiopathic Ventricular tachycardia or fibrillation have no additional structural or functional myocardial abnormalities. However, the inducibility of typical tachyarrhythmias by physical or mental stress or by catecholamine infusion suggests the involvement of the adrenergic system inthe pathogenesis of these potentially life-threatening diseases. Methods: 45 patients with idiopathic right ventricular outflow tract tachycardia (RVO-VT), 25 patients with idiopathic left Ventricular tachycardia (ILVT), 15 patients with idiopathic Ventricular fibrillation (IVF) and 10 age-matched control patients were investigated in this study. Diagnoses were made on the basis of detailed evaluation of the results of two-dimensional echocardiography, left and right ventricular angiography, coronary angiography and endomyocardial biopsy. Local presynaptic norepinephrine re-uptake was assessed using the norepinephrine analog I-123-metaiodobenzylguanidine (MIBG), SPECT and semiquantitative 33-segment bull's-eye analysis. Results: Locally reduced I-123-MIBG uptake was found in 27 of 45 RVO-VT patients (60%), 5 of 15 ILVT patients (33%) and 17 of 25 IVF patients (68%). Unlike ILVT patients, RVO-VT and IVF patients bad significantly reduced segmental I-123-MIBG uptake of the posterior wall compared with control patients. Conclusion: Patients with idiopathic tachycardia and fibrillation show;abnormal I-123-MIBG uptake, which indicates presynaptic sympathetic dysfunction. RVO-VT and IVFpatients exhibit significantly reduced I-123-MIBG uptake in the posterior left Ventricular wall, whereas ILVT patients do not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:27:03