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Titolo:
Novelty-induced increased expression of immediate-early genes c-fos and arg 3.1 in the mouse brain
Autore:
Montag-Sallaz, M; Welzl, H; Kuhl, D; Montag, D; Schachner, M;
Indirizzi:
Swiss Fed Inst Technol, Dept Neurobiol, ETH, CH-8093 Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland CH-8093 93 Zurich, Switzerland Swissland Inst Technol, Lab Behav Biol, ETH, CH-8603 Schwerzenbach, Switzer Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 enbach, Switzer Univ Hamburg, Zentrum Mol Neurobiol Hamburg, D-20246 Hamburg, Germany UnivHamburg Hamburg Germany D-20246 l Hamburg, D-20246 Hamburg, Germany
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 2, volume: 38, anno: 1999,
pagine: 234 - 246
SICI:
0022-3034(19990205)38:2<234:NIEOIG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; RAT-BRAIN; STIMULUS NOVELTY; OLFACTORY-BULB; MEMORY; FOREBRAIN; PROTEIN; MICE; SONG; DISCRIMINATION;
Keywords:
novelty; learning; memory; gustatory system; immediate-early genes; c-fos; arg 3.1; cingulate cortex; amygdala; limbic system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Montag-Sallaz, M Leibnitz Inst Neurobiol, Res Grp Neurogenet, D-39118 Magdeburg, Germany Leibnitz Inst Neurobiol Magdeburg Germany D-39118 rmany
Citazione:
M. Montag-Sallaz et al., "Novelty-induced increased expression of immediate-early genes c-fos and arg 3.1 in the mouse brain", J NEUROBIOL, 38(2), 1999, pp. 234-246

Abstract

The detection of novel stimuli is a memory-dependent process. The presented stimulus has to be compared with memory contents to judge its novelty, Inaddition, the novelty of stimuli activates attention-related processes that facilitate memory formation. To determine the involvement of limbic and neocortical brain structures in novelty detection, we exposed mice to a novel gustatory stimulus (0.5% saccharin) added to their drinking fluid. We then compared the novelty-induced expression of the two immediate-early genes (IEGs) c-fos and arg 3.1, with their expression in mice familiarized with the same stimulus or mice not exposed to that stimulus. Exposure to taste novelty increased expression of c-fos and arg 3.1 mRNA in the cingulate cortex and deep layers of the parietal cortex. In addition, c-fos mRNA expression was increased in the amygdala and arg 3.1 mRNA was increased in the dentate gyrus. Expression of c-fos and arg 3.1 was elevated 30 min after the exposure to novelty. For arg 3.1, a second peak of expression was found 4.5 h after presentation of the novel stimulus. Our results indicate that the amygdala, the dentate gyrus, and the cingulate and parietal cortices may be involved in novelty detection and associated cognitive events, and suggest that e-fas and arg 3.1 play distinct roles in these processes. (C) 1999 John Wiley & Sons, Inc.

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Documento generato il 15/07/20 alle ore 14:32:26