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Titolo:
Synthesis of N1 '-([F-18]fluoroethyl)naltrindole ([F-18]FEtNTI): A radioligand for positron emission tomographic studies of delta opioid receptors
Autore:
Mathews, WB; Kinter, CM; Palma, J; Daniels, RV; Ravert, HT; Dannals, RF; Lever, JR;
Indirizzi:
JohnsSAopkins Univ, Sch Hyg & Publ Hlth, Dept Radiol, Baltimore, MD 21205 U Johns Hopkins Univ Baltimore MD USA 21205 t Radiol, Baltimore, MD 21205 U Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 th Sci, Baltimore, MD 21205 USA USN Acad, Annapolis, MD 21402 USA USN Acad Annapolis MD USA 21402USN Acad, Annapolis, MD 21402 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 1, volume: 42, anno: 1999,
pagine: 43 - 54
SICI:
0362-4803(199901)42:1<43:SON'(A>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALTRINDOLE; N1'-(METHYL)NALTRINDOLE; BRAIN;
Keywords:
naltrindole; fluorine-18; delta opioid receptor; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Lever, JR Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Radiol, Room 2001,615 N Wolfe Johns Hopkins Univ Room 2001,615 N Wolfe St Baltimore MD USA 21205
Citazione:
W.B. Mathews et al., "Synthesis of N1 '-([F-18]fluoroethyl)naltrindole ([F-18]FEtNTI): A radioligand for positron emission tomographic studies of delta opioid receptors", J LABEL C R, 42(1), 1999, pp. 43-54

Abstract

N1'-([F-18]fluoroethyl)naltrindole ([F-18]FEtNTI), a novel analog of the delta opioid receptor antagonist naltrindole (NTI), has been prepared for evaluation as a radioligand for use in positron emission tomography. The precursor for radiolabeling was obtained in four steps from naltrexone hydrochloride with an overall yield of 47%. Nucleophilic displacement of a tosylateleaving group by [F-18]fluoride, followed by hydrogenolysis (H-2, 10% Pd/C) of a benzyl protecting group on the phenolic moiety, gave [F-18]FEtNTI. The average (n = 5) time for radiosynthesis, HPLC purification, and formulation was 77 min from end of bombardment. [F-18]FEtNTI of high radiochemical purity was obtained with an average specific activity of 846 mCi/mu mol at end of synthesis, and an average radiochemical yield of 10% (not corrected for decay).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:44:26