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Titolo:
Cochlear ablation alters acoustically induced c-fos mRNA expression in theadult rat auditory brainstem
Autore:
Luo, L; Ryan, AF; Saint Marie, RL;
Indirizzi:
House Ear Inst, Neuroanat Dept, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 t Dept, Los Angeles, CA 90057 USA Univ Calif San Diego, Dept Surg Otolaryngol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ryngol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Vet Adm Med Ctr, La Jolla, CA 92093 USA Vet Adm Med Ctr La Jolla CA USA 92093 Adm Med Ctr, La Jolla, CA 92093 USA Univ So Calif, Sch Med, Dept Otolaryngol, HNS, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ol, HNS, Los Angeles, CA 90033 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 404, anno: 1999,
pagine: 271 - 283
SICI:
0021-9967(19990208)404:2<271:CAAAIC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; CONDUCTIVE HEARING-LOSS; GUINEA-PIG; INFERIOR COLLICULUS; CELL-SIZE; RETROGRADE TRANSPORT; TRANSCRIPTION FACTOR; UNILATERAL LABYRINTHECTOMY; NEURONAL-ACTIVITY; PROTEIN-SYNTHESIS;
Keywords:
cochlear nucleus; superior olive; lateral lemniscus; inferior colliculus; activity marker; sensory deprivation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Saint Marie, RL House Ear Inst, Neuroanat Dept, 2100 W 3rd St, Los Angeles, CA 90057 USA House Ear Inst 2100 W 3rd St Los Angeles CA USA 90057 USA
Citazione:
L. Luo et al., "Cochlear ablation alters acoustically induced c-fos mRNA expression in theadult rat auditory brainstem", J COMP NEUR, 404(2), 1999, pp. 271-283

Abstract

Expression of c-fos mRNA was studied in the adult rat brain following cochlear ablations by using in situ hybridization. In normal animals, expression was produced by acoustic stimulation and was found to be tonotopically distributed in many auditory nuclei. Following unilateral cochlear ablation, acoustically driven expression was eliminated or decreased in areas normally activated by the ablated ear, e.g., the ipsilateral dorsal and ventral cochlear nuclei, dorsal periolivary nuclei, and lateral nucleus of the trapezoid body and the contralateral medial and ventral nuclei of the trapezoid body, lateral lemniscal nuclei, and inferior colliculus. These deficits did not recover, even after long survivals up to 6 months. Results also indicated that neurons in the dorsal cochlear nucleus could be activated by contralateral stimulation in the absence of ipsilateral cochlear input and that the influence of the contralateral ear was tonotopically organized. Results also indicated that c-fos expression rose rapidly and persisted for up to 6months in neurons in the rostral part of the contralateral medial nucleus of the trapezoid body following a cochlear ablation, even in the absence ofacoustic stimulation. This response may reflect a release of constitutive excitatory inputs normally suppressed by missing afferent input or changes in homeostatic gene expression related to sensory deprivation. instances oftransient, surgery-dependent increases in c-fos mRNA expression in the absence of acoustic stimulation were observed in the superficial dorsal cochlear nucleus and the cochlear nerve root on the ablated side. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:58:09