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Titolo:
A NEW PUTATIVE 5-HT1A RECEPTOR ANTAGONIST OF THE 1-ARYLPIPERAZINE CLASS OF LIGANDS
Autore:
CHOJNACKAWOJCIK E; KLODZINSKA A; DRABCZYNSKA A; PAWLOWSKI M; CHARAKCHIEVAMINOL S; CHLON G; GORCZYCA M;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,12 SMETNA ST PL-31343 KRAKOW POLAND JAGIELLONIAN UNIV,COLLEGIUM MEDICUM,DEPT CHEM TECHNOL DRUGS PL-30688 KRAKOW POLAND JAGIELLONIAN UNIV,COLLEGIUM MEDICUM,DEPT PHARMACEUT CHEM PL-30688 KRAKOW POLAND
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 7-8, volume: 30, anno: 1995,
pagine: 587 - 592
SICI:
0223-5234(1995)30:7-8<587:ANP5RA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; LOWER LIP RETRACTION; SELECTIVE ANTAGONIST; RAT; ACTIVATION; AGONISTS; 5HT1A; MODEL; DRUGS; MICE;
Keywords:
1-ARYLPIPERAZINE; 5-HT1A-ANTAGONIST; 5-HT1A-PARTIAL AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Chojnackawojcik et al., "A NEW PUTATIVE 5-HT1A RECEPTOR ANTAGONIST OF THE 1-ARYLPIPERAZINE CLASS OF LIGANDS", European journal of medicinal chemistry, 30(7-8), 1995, pp. 587-592

Abstract

5-HT1A and 5-HT2A receptor affinities of several omega-alkyl-1-arylpiperazines containing a terminal pyrimidopurine or 1,3-diazepinopurine ring system are reported. Several behavioral models demonstrated that 2,4,8-trioxo-1,3,9-trihydropyrimidino[2,1-f]purine 8 and its analogs 5and 6 may be classified as 5-HT1A postsynaptic antagonists, whereas 7, 9 and 10 are partial agonists of 5-HT1A receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:27:31