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Titolo:
Study on propionyl-L-carnitine in chronic heart failure
Autore:
Anand, IS; Francis, G; Maseri, A; Milazzotto, F; Pepine, CJ; Yusuf, S; Beaufils, P; Ferrari, R; Poole-Wilson, PA; Remme, WJ; Schlepper, M; Tavazzi, L; Visioli, O; Zarco, P; Lubsen, J; Jacono, A; Kjekshus, J; Bruzzi, P; Marubini, E; Victor, N; De Giuli, F; Opasich, C; Pasini, E; Klein, W; Bounhoure, JP; Cohen, SA; Page, E; Zannad, F; Grosser, K; Rettig-Sturmer, G; Ciampricotti, R; de Boo, J; den Hartog, F; Huige, MC; Kragten, H; Penn, H; Visser, F; Bernardi, D; Caponnetto, S; Cardoni, C; Chiariello, M; Cobelli, F; Cucchini, F; De Ambroggi, L; Del Citerna, F; De Ponti, CL; Giannuzzi, P; Giordano, A; Giusti, C; Lotto, A; Maseri, A; Magnani, B; Rengo, F; Rengo, F; Scrutinio, D; Toso, M; Vergassola, R; Zanuttini, D; Llosa, C; Montero, JM; de la Calzada, CS; Soler, S; Zarco, P; Adamec, R; Martina, B; Noble, M; Sutton, G; Yellon, D;
Indirizzi:
Univ Brescia, Spedali Civili, Cattedra Cardiol, I-25123 Brescia, Italy Univ Brescia Brescia Italy I-25123 tedra Cardiol, I-25123 Brescia, Italy
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 1, volume: 20, anno: 1999,
pagine: 70 - 76
SICI:
0195-668X(199901)20:1<70:SOPICH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSFUNCTION; RATS; TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ferrari, R Univ23rescia, Spedali Civili, Cattedra Cardiol, Ple Spedali Civili 1, I-251 Univ Brescia Ple Spedali Civili 1 Brescia Italy I-25123 I-251
Citazione:
I.S. Anand et al., "Study on propionyl-L-carnitine in chronic heart failure", EUR HEART J, 20(1), 1999, pp. 70-76

Abstract

Aims In patients with chronic heart failure, fatigue is independent of haemodynamic and neuroendocrine changes and possibly may be due to impaired muscle metabolism. Propionyl-L carnitine, a carnitine derivative, was shown in previous studies to improve muscle metabolism. The objective of this study was to evaluate the effect of propionyl-L-carnitine on exercise capacity in mild-moderate chronic heart failure patients, treated with ACE inhibitors and diuretics. Methods and Results This was a phase III, double-blind, randomized, parallel, multicentre study. The primary objective was the evaluation of the effect of propionyl-L-carnitine vs placebo on maximum exercise duration using abicycle exercise test. The primary analysis performed in the intention-to-treat population (271 and 266 patients in propionyl-L-carnitine and placebo), showed no statistically significant difference between treatments. A difference of 15 s in favour of propionyl-L-carnitine was observed in the completer/complier population (P=0.092). An a priori specified subgroup analysis on patients stratified by baseline maximum exercise duration showed a trend of improvement in propionyl-L-carnitine patients with shorter maximum exercise duration. A non a priori specified analysis in patients stratified by ejection fraction (less than or equal to 30% vs 30-40%), showed a statistically significant difference in maximum exercise duration in favour of propianyl-L-carnitine in those patients with a higher ejection fraction (40 s,P<0.01). There were no safety issues. Conclusion The study fails to meet the primary objective, but confirms thegood safety profile of propionyl-L-carnitine. An exploratory non-prespecified analysis suggests that propionyl-L-carnitine improves exercise capacityin patients with preserved cardiac function. This hypothesis needs to be confirmed by aspecific tailored study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:23:27