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Titolo:
Developmental regulation of gastric somatostatin secretion in the sheep
Autore:
Grabau, BJ; Zavros, Y; Hardy, KJ; Shulkes, A;
Indirizzi:
Univ Melbourne, Austin & Repatriat Med Ctr, Dept Surg, Melbourne, Vic 3084, Univ Melbourne Melbourne Vic Australia 3084 pt Surg, Melbourne, Vic 3084,
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 2, volume: 140, anno: 1999,
pagine: 603 - 608
SICI:
0013-7227(199902)140:2<603:DROGSS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED ACID-SECRETION; FUNDIC MUCOSAL CELLS; PERFUSED RAT STOMACH; MONOCLONAL-ANTIBODY IMMUNONEUTRALIZATION; HISTAMINE H-3 RECEPTORS; IMMUNOHISTOCHEMICAL LOCALIZATION; PRIMARY CULTURE; OVINE FETUS; RELEASE; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Shulkes, A Univ Melbourne, Austin & Repatriat Med Ctr, Dept Surg, Melbourne, Vic 3084, Univ Melbourne Melbourne Vic Australia 3084 lbourne, Vic 3084,
Citazione:
B.J. Grabau et al., "Developmental regulation of gastric somatostatin secretion in the sheep", ENDOCRINOL, 140(2), 1999, pp. 603-608

Abstract

Gastric somatostatin (SRIF) regulates gastric acidity by inhibiting gastric acid and gastrin secretion. SRIF secretion is increased by gastric acidity and also directly by regulators of gastric acid secretion such as gastrin. This direct effect has not been described in the developing animal, nor have the roles of intermediaries such as histamine and gastric acidity been defined. The present study aimed to establish the regulatory role of gastrin and histamine during development on SRIF secretion and also to determine whether the effects of gastrin and histamine are independent of gastric pH. Pentagastrin and histamine were infused on separate occasions into fetal sheep, newborn lambs, and 28-day-old lambs. To determine the roles of endogenous histamine and gastric pH, ranitidine (a histamine-2 receptor antagonist) and omeprazole (a H+/K+ ATPase inhibitor) were coinfused with the agonists. Plasma SRIF and gastrin concentrations were measured by RIA. Pentagastrin stimulated SRIF secretion in the fetus after 131 days of gestation (termis 147 days), whereas stimulation by histamine was effective only after birth. The SRIF stimulatory effect of pentagastrin in 28-day-old lambs was abolished by ranitidine, which also reduced this effect in the adult sheep. This inhibitory effect of ranitidine was shown to be a result of blockade ofstimulatory H-2 receptors, because in the adult blockade of acid secretionwith omeprazole failed to attenuate the response of histamine. These results indicate that in the fetus, gastrin receptors, but not histamine receptors, are functionally involved in the stimulation of SRIF secretion. After birth, both gastrin and histamine stimulate SRIF, but the effect of gastrin is mediated at least in part by the release of endogenous histamine. These responses occur independently of changes in gastric acidity, supporting theconcept of a direct negative feedback between SRIF and gastrin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:26:44