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Titolo:
Instillation of calf lung surfactant extract (calfactant) is beneficial inpediatric acute hypoxemic respiratory failure
Autore:
Willson, DF; Zaritsky, A; Bauman, LA; Dockery, K; James, RL; Conrad, D; Craft, H; Novotny, WE; Egan, EA; Dalton, H;
Indirizzi:
Childrens Med Ctr, Charlottesville, VA USA Childrens Med Ctr Charlottesville VA USA ed Ctr, Charlottesville, VA USA Childrens Hosp Kings Daughters, Norfolk, VA USA Childrens Hosp Kings Daughters Norfolk VA USA Daughters, Norfolk, VA USA Fairfax Hosp, Falls Church, VA 22046 USA Fairfax Hosp Falls Church VA USA22046 x Hosp, Falls Church, VA 22046 USA Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA ray Sch Med, Winston Salem, NC USA Henrico Doctors Hosp, Richmond, VA USA Henrico Doctors Hosp Richmond VA USA rico Doctors Hosp, Richmond, VA USA Carillon Med Ctr Children, Greenville, NC USA Carillon Med Ctr Children Greenville NC USA Children, Greenville, NC USA E Carolina Med Ctr, Greenville, NC USA E Carolina Med Ctr Greenville NC USA arolina Med Ctr, Greenville, NC USA ONY Inc, Amherst, NY USA ONY Inc Amherst NY USAONY Inc, Amherst, NY USA Georgetown Univ, Washington, DC 20057 USA Georgetown Univ Washington DC USA 20057 wn Univ, Washington, DC 20057 USA
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 1, volume: 27, anno: 1999,
pagine: 188 - 195
SICI:
0090-3493(199901)27:1<188:IOCLSE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTRESS-SYNDROME; AEROSOLIZED SURFACTANT; EXOGENOUS SURFACTANT; CONTROLLED TRIAL; CLINICAL-TRIAL; PRETERM LAMBS; CHILDREN; MORTALITY; DISEASE; THERAPY;
Keywords:
acute hypoxemic respiratory failure; adult respiratory distress syndrome; barotrauma; mechanical ventilation; oxygenation index; pneumonia; respiratory failure; surfactant; ventilation index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Willson, DF Univ,Virginia, Hlth Sci Ctr, Div Pediat Crit Care, Box 386, Charlottesville Univ Virginia Box 386 Charlottesville VA USA 22908 lottesville
Citazione:
D.F. Willson et al., "Instillation of calf lung surfactant extract (calfactant) is beneficial inpediatric acute hypoxemic respiratory failure", CRIT CARE M, 27(1), 1999, pp. 188-195

Abstract

Objective: Prospective study of the efficacy of calf lung surfactant extract in pediatric respiratory failure. Design: Multi-institutional, prospective, randomized, controlled, unblinded trial. Setting: Eight pediatric intensive care units (ICU) of tertiary medical centers. Patients: Forty-two children with acute hypoxemic respiratory failure characterized by diffuse, bilateral pulmonary infiltrates, need for ventilatorysupport, and an oxygenation index of greater than or equal to 7. Intervention: Instillation of intratracheal surfactant (80 mL/m(2)). Measurements and Main Results: Ventilator parameters, arterial blood gases, and derived oxygenation and ventilation indices were recorded before and at intervals after surfactant administration. complications and outcome measures, including mortality, duration of mechanical ventilation, and length of pediatric ICU and hospital stay, were also examined. Patients who received surfactant demonstrated rapid improvement In oxygenation and, on average, were extubated 4.2 days (32%) sooner and spent 5 fewer days (30%) in pediatric intensive care than control patients. There was no difference in mortality or overall hospital stay. Surfactant administration was associated with no serious adverse effects. Conclusions: Administration of calf lung surfactant extract, calfactant, appears to be safe and is associated with rapid improvement in oxygenation, earlier extubation, and decreased requirement for intensive care in children with acute hypoxemic respiratory failure. Further study is needed, however, before widespread use in pediatric respiratory failure can be recommended.

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Documento generato il 04/04/20 alle ore 15:08:55