Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delayed intracranial hypertension: Relationship to leukocyte count
Autore:
Souter, MJ; Andrews, PJD; Pereirinha, MR; Signorini, DF; Jones, PA; Miller, JD;
Indirizzi:
UnivScotlandgh, Western Gen Hosp, Dept Anaesthesia, Edinburgh, Midlothian,Univ Edinburgh Edinburgh Midlothian Scotland sia, Edinburgh, Midlothian, Univ,Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Edinburgh, Midlothian Univ Edinburgh Edinburgh Midlothian Scotland osci, Edinburgh, Midlothian Hosp Santa Maria, Lisbon, Portugal Hosp Santa Maria Lisbon PortugalHosp Santa Maria, Lisbon, Portugal
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 1, volume: 27, anno: 1999,
pagine: 177 - 181
SICI:
0090-3493(199901)27:1<177:DIHRTL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAD-INJURY; RAT-BRAIN; INTERLEUKIN-6 LEVELS; TRAUMATIC INJURY; INTENSIVE-CARE; CYTOKINES; TISSUE; IL-6; PRESSURE; PLASMA;
Keywords:
brain injury; coma; critical care; cytokines; hypotension; hypoxemia; intracranial hypertension; leukocytosis; monitoring; outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Souter, MJ UnivScotlandgh, Western Gen Hosp, Dept Anaesthesia, Edinburgh, Midlothian, Univ Edinburgh Edinburgh Midlothian Scotland rgh, Midlothian,
Citazione:
M.J. Souter et al., "Delayed intracranial hypertension: Relationship to leukocyte count", CRIT CARE M, 27(1), 1999, pp. 177-181

Abstract

Objective: Secondary intracranial hypertension has been linked to leukocytosis. We examined our data bank containing physiologic recordings and outcome data of severely head injured patients to investigate the relationship between delayed increases in intracranial pressure (ICP), defined as occurring after a 12-hr period of normal ICP values, and leukocytosis. Design: A retrospective study of observational data. Setting: Regional neurosurgical unit and intensive care unit. Patients: Sixty-four patients suffered increased ICP >20 mm Hg. Thirty-five patients fulfilled selection criteria for delayed increases in ICP (group1). Twenty-nine patients with increased ICP with no preceding or intervening periods of normal ICP were selected as a comparison group (group 2). Measurements and Main Results: Comparison of 12-month outcome revealed that 11% of group 1 patients died, with 49% remaining severely disabled, in contrast to group 2, where 35% of patients died and 14% were left severely disabled (p =.021). The pattern of outcome was independent of monitoring time, or injury severity. Regression modeling was performed for prediction of delayed increase in ICP. Of 46 patients with an initial increase then decrease in leukocyte count in the first 48 hrs, 65% experienced delayed increases in ICP, as compared with 18% of the 11 patients without this pattern (p =.011). Conclusions: Patients with delayed increases have a significantly different pattern of outcome. Change in leukocyte count from admission to day 2 is a significant predictor of such a delayed increase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:27:27