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Titolo:
Flumazenil in drug overdose: Randomized, placebo-controlled study to assess cost effectiveness
Autore:
Barnett, R; Grace, M; Boothe, P; Latozek, K; Neal, C; Legatt, D; Finegan, BA;
Indirizzi:
Univ Alberta, Dept Anaesthesia, Edmonton, AB T6G 2M7, Canada Univ AlbertaEdmonton AB Canada T6G 2M7 sia, Edmonton, AB T6G 2M7, Canada Univ Alberta, Dept Econ, Edmonton, AB T6G 2M7, Canada Univ Alberta Edmonton AB Canada T6G 2M7 con, Edmonton, AB T6G 2M7, Canada Univ Alberta Hosp, Dept Emergency Med, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp, Dept Lab Med & Pathol, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 1, volume: 27, anno: 1999,
pagine: 78 - 81
SICI:
0090-3493(199901)27:1<78:FIDORP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE ANTAGONIST; DOUBLE-BLIND; DIAGNOSTIC UTILITY; UNKNOWN ETIOLOGY; EMPIRIC USE; COMA; PATIENT; 1980S;
Keywords:
overdose; flumazenil; coma; costs; cost effectiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Barnett, R Univ Alberta, Dept Anaesthesia, Edmonton, AB T6G 2M7, Canada Univ Alberta Edmonton AB Canada T6G 2M7 on, AB T6G 2M7, Canada
Citazione:
R. Barnett et al., "Flumazenil in drug overdose: Randomized, placebo-controlled study to assess cost effectiveness", CRIT CARE M, 27(1), 1999, pp. 78-81

Abstract

Objective: To investigate cost effectiveness of administration of flumazenil to patients presenting with suspected acute drug overdose. Design: Doubie-blind, prospective, placebo-controlled randomized study. Setting: University teaching hospital. Patients: Forty-three adults presenting with suspected drug overdose and having a Glasgow Coma Scale (GCS) score of <13. Patients with known benzodiazepine/tricyclic ingestion were excluded. Interventions: Intravenous administration of flumazenil (up to 2 mg) or placebo. Measurements and Main Results: Individual patient costs were assessed and data aggregated for each treatment group. Major diagnostic and therapeutic interventions were recorded and between group comparisons performed. Clinical response to study drug administration was assessed by obtaining pre- andpost drug GCS scores and observation of the patient for at least 180 mins for signs of resedation. Aggregate cost or number of major diagnostic and therapeutic interventionswere not different between groups. Patients randomized to the flumazenil group showed a marked increase in GCS score (7.4 to 11.8) compared with those in the placebo group (8.2 to 8.6). Conclusion: Use of flumazenil in intentional drug overdose unknown etiology is not cast effective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:12:06