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Titolo:
Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver
Autore:
Bahnmaier, AH; Woesle, B; Thomas, H;
Indirizzi:
Univ Ulm, Dept Physiol Chem, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069 lm, Dept Physiol Chem, D-89069 Ulm, Germany
Titolo Testata:
CHIRALITY
fascicolo: 2, volume: 11, anno: 1999,
pagine: 160 - 165
SICI:
0899-0042(1999)11:2<160:SNOTTA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY-MASS-SPECTROMETRY; MONOAMINE-OXIDASE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; METHYLISOQUINOLINIUM ION; DOPAMINERGIC NEUROTOXIN; TYROSINE-HYDROXYLASE; INDUCED PARKINSONISM; SUBSTANTIA-NIGRA; HUMAN-BRAIN; RAT-BRAIN;
Keywords:
enantiomers; high-performance liquid chromatography; radioassay; Parkinsonism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, H Univ Ulm, Dept Physiol Chem, Albert Einstein Allee 11, D-89069 Ulm, Germany Univ Ulm Albert Einstein Allee 11 Ulm Germany D-89069 , Germany
Citazione:
A.H. Bahnmaier et al., "Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver", CHIRALITY, 11(2), 1999, pp. 160-165

Abstract

Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline (7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) and salsolidine (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) by amineN-methyltransferase A isolated from bovine liver is reported. Incubation with S-adenosylmethionine as cosubstrate revealed that in case of isosalsoline, an endogenous tetrahydroisoquinoline alkaloid, the (+)-(R)-enantiomer, is preferentially methylated, whereas in the case of salsolidine the (-)-(S)-enantiomer is preferentially methylated. The results were obtained by using two independent methods, namely a radioassay and HPLC following separateincubation experiments. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:29:48