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Titolo:
Cobalt-55 positron emission tomography of ipsilateral thalamic and crossedcerebellar hypometabolism after supratentorial ischaemic stroke
Autore:
De Reuck, J; Stevens, H; Jansen, H; Keppens, J; Strijckmans, K; Goethals, P; Lemahieu, I; Santens, P; Korf, J;
Indirizzi:
State Univ Ghent Hosp, Dept Neurol, B-9000 Ghent, Belgium State Univ GhentHosp Ghent Belgium B-9000 Neurol, B-9000 Ghent, Belgium State Univ Ghent Hosp, UZ RUG, PET Ctr, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 ET Ctr, B-9000 Ghent, Belgium Univ Groningen Hosp, Dept Biol Psychiat, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands chiat, Groningen, Netherlands State Univ Ghent, Dept Elect & Informat Syst, Ghent, Belgium State Univ Ghent Ghent Belgium pt Elect & Informat Syst, Ghent, Belgium State Univ Ghent, Inst Sci Nucl, Analyt Chem Lab, Ghent, Belgium State Univ Ghent Ghent Belgium ci Nucl, Analyt Chem Lab, Ghent, Belgium
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 1, volume: 9, anno: 1999,
pagine: 40 - 44
SICI:
1015-9770(199901/02)9:1<40:CPETOI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY INFARCTION; ISCHEMIC STROKE; BLOOD-FLOW; OXYGEN-METABOLISM; VASCULAR-RESPONSE; DIASCHISIS; BRAIN; ACETAZOLAMIDE; ATROPHY; HYPOPERFUSION;
Keywords:
positron emission tomography; Cobalt-55; ischaemic stroke; ipsilateral thalamic hypometabolism; crossed cerebellar hypometabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: De Reuck, J State Univ Ghent Hosp, Dept Neurol, De Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp De Pintelaan 185 Ghent Belgium B-9000 m
Citazione:
J. De Reuck et al., "Cobalt-55 positron emission tomography of ipsilateral thalamic and crossedcerebellar hypometabolism after supratentorial ischaemic stroke", CEREB DIS, 9(1), 1999, pp. 40-44

Abstract

Cobalt-55 (Co-55) is a positron emission tomography (PET) tracer used to demonstrate brain damage, possibly associated to calcium-mediated processes. The degree of Co-55 accumulation correlates with the severity of ischaemiain stroke patients. It is still a matter of debate whether ipsilateral thalamic hypometabolism (ITH) and crossed cerebellar hypometabolism (CCH), occurring after middle cerebral artery (MCA) infarcts, represent only a metabolic depression of these remote regions or can lead to structural damage. The present study investigates whether an increased Co-55 influx can be demonstrated with PET in ITH and CCH after MCA infarcts. About half of the patients with ITH and CCH had a significant degree of Co-55 uptake in, respectively, the ipsilateral thalamus and the contralateral cerebellar hemisphere. It was observed in patients with severe signs of stroke on admission and poor clinical outcome, and correlated well with the degree of Co-55 influx within the supratentorial infarct, The present study demonstrates that ITH and CCH after MCA infarction can represent structural damage in these remote areas that occurs during the second week after stroke onset.

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Documento generato il 02/04/20 alle ore 22:21:51