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Titolo:
Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis - A clinicopathologic report of four cases
Autore:
Wurthner, JU; Kohler, G; Behringer, D; Lindemann, A; Mertelsmann, R; Lubbert, M;
Indirizzi:
Univ Freiburg, Med Ctr, Dept Hematol Oncol, D-79106 Freiburg, Germany UnivFreiburg Freiburg Germany D-79106 Oncol, D-79106 Freiburg, Germany Univ Freiburg, Med Ctr, Dept Pathol, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 Pathol, D-79106 Freiburg, Germany
Titolo Testata:
CANCER
fascicolo: 2, volume: 85, anno: 1999,
pagine: 368 - 374
SICI:
0008-543X(19990115)85:2<368:LFBHCT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL MYELOCYTIC-LEUKEMIA; ACUTE MYELOMONOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; PULMONARY LEUKOSTASIS; THERAPEUTIC LEUKAPHERESIS; LYSIS PNEUMONOPATHY; CELL-LINES; DIFFERENTIATION; CYTOREDUCTION; PATHOGENESIS;
Keywords:
adhesion molecules; leukapheresis; cytosine arabinoside; acute myelomonocytic leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lubbert, M Univburg,burg, Med Ctr, Dept Hematol Oncol, Hugstetter Str 55, D-79106 Frei Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 Frei
Citazione:
J.U. Wurthner et al., "Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis - A clinicopathologic report of four cases", CANCER, 85(2), 1999, pp. 368-374

Abstract

BACKGROUND. Pulmonary and cerebral leukostasis, or parenchymal hemorrhage in these organs, are well-known early complications developing in patients with acute myeloid leukemia (AML), particularly when myelomonocytic features, hyperleukocytosis, and/or a coagulation disorder are initially present. Commonly, these complications arise during increasing leukocyte counts (WBCs). METHODS. The authors describe four patients with AML and hyperleukocytosiswho developed leukostasis followed by parenchymal hemorrhage. RESULTS. Bleeding in all patients occurred while their WBCs were decreasing following cytosine-arabinoside chemotherapy, and in the absence of disseminated intravascular coagulation or severe thrombocytopenia. Radiologic andhistopathologic findings underscoring possible mechanisms are presented inthe article. CONCLUSIONS. Alterations of cell adhesion associated with chemotherapy-induced blast lysis or cellular differentiation are possible factors contributing to this particular sequence (cytosine arabinoside-based chemotherapy, leukostasis, and subsequent hemorrhage). Prophylactic measures for managing this early complication of AML treatment include leukapheresis to reduce the WBC prior to the initiation of chemotherapy. (C) 1999 American Cancer Society.

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Documento generato il 08/08/20 alle ore 08:36:04