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Titolo:
Levels of serum immunoglobulin G, CSF IgG and IgG index in acute bacterialmeningitis
Autore:
Giasuddin, ASM; Shembesh, NM; El-Bargathy, SM; Kashbur, IM; Rao, BN;
Indirizzi:
Al Arab Med Univ, Fac Med, Dept Lab Med, Benghazi, Libya Al Arab Med UnivBenghazi Libya Fac Med, Dept Lab Med, Benghazi, Libya Al Arab Med Univ, Fac Med, Dept Paediat, Benghazi, Libya Al Arab Med UnivBenghazi Libya Fac Med, Dept Paediat, Benghazi, Libya Al Arab Med Univ, Fac Med, Dept Microbiol, Benghazi, Libya Al Arab Med Univ Benghazi Libya ac Med, Dept Microbiol, Benghazi, Libya
Titolo Testata:
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 4, volume: 55, anno: 1998,
pagine: 253 - 257
SICI:
0967-4845(199812)55:4<253:LOSIGC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; NEUROLOGICAL DISORDERS; DEXAMETHASONE; PRINCIPLES; FORMULAS; CHILDREN; ALBUMIN;
Keywords:
acute bacterial meningitis; IgG index; immunoglobulin G;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Giasuddin, ASM Al Arab Med Univ, Fac Med, Dept Lab Med, POB 17383, Benghazi, Libya Al Arab Med Univ POB 17383 Benghazi Libya Benghazi, Libya
Citazione:
A.S.M. Giasuddin et al., "Levels of serum immunoglobulin G, CSF IgG and IgG index in acute bacterialmeningitis", BR J BIOMED, 55(4), 1998, pp. 253-257

Abstract

This study characterised the levels of serum immunoglobulin G (IgG), cerebrospinal fluid IgG (CSF IgG) and IgG index as an aid to the diagnosis and prognosis of acute bacterial meningitis (ABM). A total of 28 patients with proven ABM at admission (age range: one month to 10 years; 17 males, 11 females) (group A) and 17 age- and sex-matched control children (group B) were studied. Levels were also compared between patients with neurological morbidity (n=4; group C) and without neurological morbidity (n=24; group D) who were subsets of group A. In addition, patients were divided randomly into tao groups based on the treatment received (i.e. ceftriaxone together with dexamethasone [n=11; group A1] and ceftriaxone only [n=9; group A2] to assess the effect of dexamethasone. The results (mean +/- SEM) demonstrated intrathecal synthesis of IgG in ABM (group A vs group B: CSF IgG (mg/L): 92.64 /- 23.54 vs 2.12 +/- 1.08, P<0.002; IgG index: 0.959 +/- 0.481 vs 0.029 +/- 0.006, P<0.001) which showed good diagnostic significance. In the patients with permanent neurological morbidity (group C) vs healthy survivors (group D), the CSF IgG and IgG index showed good prognostic significance (groupC ps group D: CSF IgG (mg/L): 10.75 +/- 9.75 vs 106.24 +/- 29.37, P<0.01; IgG index: 0.046 +/- 0.039 vs 1.132 +/- 0.568, P<0.05). Dexamethasone lowered CSF-IgG and IgG-index levels, but the effect was not statistically significant (group Al vs group A2: P>0.1).

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Documento generato il 26/01/20 alle ore 00:41:31