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Titolo:
Use of peripheral quantitative computed tomography for densitometry of thefemoral neck and spine in cynomolgus monkeys (Macaca fascicularis)
Autore:
Hotchkiss, CE;
Indirizzi:
Wake Forest Univ, Sch Med, Comparat Med Sect, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
BONE
fascicolo: 2, volume: 24, anno: 1999,
pagine: 101 - 107
SICI:
8756-3282(199902)24:2<101:UOPQCT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY ABSORPTIOMETRY; BONE-DENSITY; PROXIMAL FEMUR; CORTICAL BONE; POSTMENOPAUSAL WOMEN; COMPRESSIVE STRENGTH; LUMBAR VERTEBRAE; ASH DENSITY; OSTEOPOROSIS; MASS;
Keywords:
quantitative computed tomography; monkey; femoral neck; vertebra; densitometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hotchkiss, CE WakeNCorest Univ, Sch Med, Comparat Med Sect, Med Ctr Blvd, Winston Salem, Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 em,
Citazione:
C.E. Hotchkiss, "Use of peripheral quantitative computed tomography for densitometry of thefemoral neck and spine in cynomolgus monkeys (Macaca fascicularis)", BONE, 24(2), 1999, pp. 101-107

Abstract

Quantitative computed tomography (QCT) allows for the separate densitometric examination of cortical and cancellous bone in vivo. With the new peripheral QCT (pQCT) instrument (the Norland/Stratec XCT-3000A), we evaluated the clinically relevant axial sites of spine and femoral neck in nonhuman primates in vivo. The reproducibility was good (coefficient of variation [CV] <3% at both sites for cortical, trabecular, and total bone mineral density [BMD]; CV 3%-7% for bone mineral content [BMC] and cross-sectional bone area). One hundred sixty intact female cynomolgus monkeys (M. fascicularis) were scanned at the femoral neck, There was less variability among monkeys incortical BMD (mean 802 mg/mL, CV 6%) as opposed to trabecular BMD (mean 334 mg/mL, CV 28%) or transition zone BMD (mean 457 mg/mL, CV 12%), Scans were performed on lumbar vertebrae (L-4, L-5, and L-6) from five monkeys in vivo and ex vivo. Removal of soft tissue increased measured BMD, Decreasing voxel size from 0.4 mm to 0.2 mm increased measured BMD by diminishing the partial volume effect. Factor analysis demonstrated the expected relationships between pQCT parameters and physical measurement of bone mass and volumeex vivo. Preliminary results in eight ovariectomized and eight reproductively intact monkeys revealed a lower transition zone BMD at the femoral neck, and lower total BMD of the vertebral body in estrogen-deficient animals. (Bone 24:101-107; 1999) (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:17:03