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Titolo:
Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives
Autore:
Leboyer, M; Philippe, A; Bouvard, M; Guilloud-Bataille, M; Bondoux, D; Tabuteau, F; Feingold, J; Mouren-Simeoni, MC; Launay, JM;
Indirizzi:
Hop La Pitie Salpetriere, INSERM U289, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 U289, F-75651 Paris 13, France Fac Jussieu, INSERM U155, Paris, France Fac Jussieu Paris FranceFac Jussieu, INSERM U155, Paris, France Hopncebert Debre, Serv Psychopathol Enfant & Adolescent, F-75019 Paris, Fra Hop Robert Debre Paris France F-75019 t & Adolescent, F-75019 Paris, Fra Hopis,riboisiere, Ctr Rech Claude Bernard, IFR 6, Serv Biochim, F-75475 Par Hop Lariboisiere Paris France F-75475 , IFR 6, Serv Biochim, F-75475 Par
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 45, anno: 1999,
pagine: 158 - 163
SICI:
0006-3223(19990115)45:2<158:WBSAPB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRANIAL NEURAL CREST; INFANTILE-AUTISM; MONONUCLEAR-CELLS; 1ST-DEGREE RELATIVES; CHILDREN; DISORDER; PARENTS; TWIN;
Keywords:
autism; genetic; serotonin; beta-endorphin; familial aggregation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Leboyer, M HopancePitie Salpetriere, INSERM U289, 47 Blvd de Hop, F-75651 Paris 13, Fr Hop La Pitie Salpetriere 47 Blvd de Hop Paris France 13 13, Fr
Citazione:
M. Leboyer et al., "Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives", BIOL PSYCHI, 45(2), 1999, pp. 158-163

Abstract

Background: Whole blood serotonin (5-HT) and C-terminally directed beta-endorphin protein immunoreactivity (C-ter-beta-EP-ir) are known to be elevated in autistic subjects and might be possible markers of genetic liability to autism. This study thus investigates the familial aggregation of 5-HT andof C-ter-beta-EP-ir levels in first degree relatives of autistic probands. Methods: In a sample of 62 autistic subjects and 122 of their first-degreerelatives, compared to age and sex-matched controls, we measured 5-HT by radioenzymology and C-ter-beta-EP-ir by radioimmunoassay,Results: We confirm the previously reported familiality of hyperserotoninemia in autism as mothers (51%), fathers (45%) and siblings (87%) have elevated levels of 5-HT, and we reveal presence of elevated levels of C-ter-beta-EP-ir in mothers (53%) of autistic subjects. Conclusions: Familial aggregation of quantitative variables, such as concentration of neurotransmitters, within unaffected relative could serve as anintermediate phenotype and might thus help the search of genetic susceptibility factors in autism. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:30:52