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Titolo:
A NOVEL 4-KB INTERLEUKIN-13 RECEPTOR-ALPHA MESSENGER-RNA EXPRESSED INHUMAN B-CELLS, T-CELLS, AND ENDOTHELIAL-CELLS ENCODING AN ALTERNATE TYPE-II INTERLEUKIN-4 INTERLEUKIN-13 RECEPTOR/
Autore:
GAUCHAT JF; SCHLAGENHAUF E; FENG NP; MOSER R; YAMAGE M; JEANNIN P; ALOUANI S; ELSON G; NOTARANGELO LD; WELLS T; EUGSTER HP; BONNEFOY JY;
Indirizzi:
GLAXO WELLCOME RES & DEV LTD,GENEVA BIOMED RES INST,DEPT IMMUNOL,14 CHEMIN AULX CH-1228 PLAN LES OUATES SWITZERLAND SWISS FED INST TECHNOL,INST TOXICOL SCHWERZENBACH SWITZERLAND UNIV BRESCIA,DIPARTIMENTO MATERNOINFANTILE BRESCIA ITALY
Titolo Testata:
European Journal of Immunology
fascicolo: 4, volume: 27, anno: 1997,
pagine: 971 - 978
SICI:
0014-2980(1997)27:4<971:AN4IRM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCE IGE SYNTHESIS; SIGNAL-TRANSDUCTION; GAMMA-CHAIN; EPSILON-TRANSCRIPTS; ADHESION MOLECULE-1; HUMAN EOSINOPHILS; CD40 LIGAND; IN-VITRO; IL-4; INSULIN;
Keywords:
INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-13 RECEPTOR; INTERLEUKIN-4 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Gauchat et al., "A NOVEL 4-KB INTERLEUKIN-13 RECEPTOR-ALPHA MESSENGER-RNA EXPRESSED INHUMAN B-CELLS, T-CELLS, AND ENDOTHELIAL-CELLS ENCODING AN ALTERNATE TYPE-II INTERLEUKIN-4 INTERLEUKIN-13 RECEPTOR/", European Journal of Immunology, 27(4), 1997, pp. 971-978

Abstract

A 4 kb human interleukin-13 receptor (IL-13R) chain cDNA was cloned from a B cell cDNA library using expressed sequence tags homologous to mouse IL-13R as probes. The deduced protein sequence shows a significant level of sequence identity with the IL-SR and the human IL-13R identified recently by expression cloning. The cytoplasmic region is very highly conserved between human and mouse homologs and contains a consensus binding motif for a signal transducer and activator of transcription. The cDNA encodes a protein binding IL-13 when expressed alone which participates in a receptor complex for both IL-4 and IL-13 when expressed in conjunction with the IL-4R alpha chain. Transcripts for thisIL-13R chain could be detected in most tissues and organs studied andin T, B, endothelial cells, basophilic, immature mast cell, and monocytic cell lines. The pattern of expression is different from the otherrecently cloned IL-13R molecule, and correlates with sites where IL-4and IL-13 signaling is known to occur. This novel receptor is therefore likely to be implicated in reactions involved in IgE responses, T helper 2 differentiation, adhesion of leukocytes to endothelium, and therefore in pathological phenomena such as allergy, atopy, and asthma.

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Documento generato il 27/01/21 alle ore 02:25:03