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Titolo:
Maternal folate status during extended lactation and the effect of supplemental folic acid
Autore:
Mackey, AD; Picciano, MF;
Indirizzi:
Penn State Univ, Dept Nutr, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 r, University Pk, PA 16802 USA Penn State Univ, Grad Program Nutr, University Pk, PA 16802 USA Penn StateUniv University Pk PA USA 16802 r, University Pk, PA 16802 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 2, volume: 69, anno: 1999,
pagine: 285 - 292
SICI:
0002-9165(199902)69:2<285:MFSDEL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HUMAN-MILK FOLATE; LIQUID-CHROMATOGRAPHY; TOTAL HOMOCYSTEINE; NONPREGNANT WOMEN; BREAST-MILK; PLASMA; EXTRACTION; PREGNANCY; PRODUCTS;
Keywords:
lactation; plasma folate; erythrocyte folate; milk folate; dietary folate intake; plasma homocysteine; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Picciano, MF PennSAtate Univ, Dept Nutr, S129C Henderson Bldg, University Pk, PA 16802 U Penn State Univ S129C Henderson Bldg University Pk PA USA 16802
Citazione:
A.D. Mackey e M.F. Picciano, "Maternal folate status during extended lactation and the effect of supplemental folic acid", AM J CLIN N, 69(2), 1999, pp. 285-292

Abstract

Background: Folate requirements during lactation are not well established. Objective: We assessed the effects of dietary and supplemental folate intakes during extended lactation. Design: Lactating women (n = 42) were enrolled in a double-blind, randomized, longitudinal supplementation trial and received either 0 or 1 mg folic acid/d. At 3 and 6 mo postpartum, maternal folate status was assessed by measuring erythrocyte, plasma, milk, and dietary folate concentrations; plasma homocysteine; and hematologic indexes. Infant anthropometric measures of growth, milk intake, and folate intake were also assessed. Results: In supplemented women, values at 6 mo for erythrocyte and milk folate concentrations and for plasma homocysteine were not significantly different from those at 3 mo. In supplemented women compared with unsupplemented women at 6 Ino, values for erythrocyte folate (840 compared with 667 nmol/L; P < 0.05), hemoglobin (140 compared with 134 g/L; P < 0.02), and hematocrit (0.41 compared with 0.39; P < 0.02) were higher and values for reticulocytes were lower. In unsupplemented women, milk folate declined from 224 to 187 nmol/L (99 to 82 ng/mL), whereas plasma homocysteine increased from 6.7 to 7.4 mu mol/L. Dietary folate intake was not significantly different between groups (380 +/- 19 mu g/d) and at 6 mo was correlated with plasma homocysteine in unsupplemented women (r = -0.53, P < 0.01) and with plasma folate in supplemented women (r = 0.49, P < 0.02). Conclusions: A dietary folate intake of approximate to 380 mu g/d may not be sufficient to prevent mobilization of maternal folate stores during lactation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:14:22