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Titolo:
A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations
Autore:
Mensink, RP; van Houwelingen, AC; Kromhout, D; Hornstra, G;
Indirizzi:
Maastricht Univ, Dept Human Biol, NL-6200 MD Maastricht, Netherlands Maastricht Univ Maastricht Netherlands NL-6200 MD aastricht, Netherlands Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 2, volume: 69, anno: 1999,
pagine: 213 - 219
SICI:
0002-9165(199902)69:2<213:AVECRI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
E SUPPLEMENTATION; PLASMA-LIPIDS; OIL; ANTIOXIDANT; DISEASE; HUMANS; PEROXIDATION; CHOLESTEROL; TOCOPHEROLS; REDUCTASE;
Keywords:
tocotrienols; cholesterol; HDL cholesterol; triacylglycerols; aggregation; coagulation; fibrinolysis; lipid peroxides; humans; thromboxane B-2; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mensink, RP Maastrichtdsniv, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlan Maastricht Univ POB 616 Maastricht Netherlands NL-6200 MD lan
Citazione:
R.P. Mensink et al., "A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations", AM J CLIN N, 69(2), 1999, pp. 213-219

Abstract

Background: Tocotrienols, lipid-soluble antioxidants with vitamin E activity, have been reported to lower LDL-cholesterol concentrations and plateletaggregation in men, but results are contradictory. Objective: To examine in detail the effects of a vitamin E concentrate rich in tocotrienols on serum lipoproteins and on platelet function in men at risk for cardiovascular disease. Design: In this randomized, double-blind, placebo-controlled parallel trial, 20 men received daily for 6 wk 4 capsules, each containing 35 mg tocotrienols and 20 mg alpha-tocopherol; 20 other men received 4 capsules daily, each providing 20 mg alpha-tocopherol. All men had concentrations of serum total cholesterol between 6.5 and 8.0 mmol/L or lipoprotein(a) concentrations > 150 mg/L. Results: Compliance was confirmed by changes in serum tocopherol and tocotrienol concentrations. Serum LDL cholesterol in the tocotrienol group was 4.80 mmol/L before and 4.79 mmol/L after intervention, and increased from 4.70 to 4.86 mmol/L in the placebo group (95% CI for the difference: -0.54, 0.19 mmol/L; P = 0.333). Also, changes in HDL cholesterol, triacylglycerol, lipoprotein(a), and lipid peroxide concentrations did not differ between the groups. After adjustment for differences in initial values, no effects were found on collagen-induced platelet aggregation velocity, maximum aggregation, or thromboxane Bz formation in citrated whole blood. ATP release, however, was lower in the tocotrienol group. Urinary thromboxane B-2 and 11-keto-thromboxane B-2 concentrations and coagulation and fibrinolytic measuresdid not change. Conclusion: The tocotrienol supplements used had no marked favorable effects on the serum lipoprotein profile or on platelet function in men with slightly elevated lipid concentrations.

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Documento generato il 07/04/20 alle ore 04:11:58