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Titolo:
Costimulatory activity of inactivated influenza virus in response of humanperipheral blood mononuclear cells to phytohemagglutinin A and anti-CD3 antibody
Autore:
Eisenthal, A; Marder, O; Gelfend, A; Skornick, Y; Lifschitz-Mercer, B;
Indirizzi:
Sourasky Tel Aviv Med Ctr, Inst Pathol, Tel Aviv, Israel Sourasky Tel AvivMed Ctr Tel Aviv Israel Inst Pathol, Tel Aviv, Israel Sourasky Tel Aviv Med Ctr, Dept Surg A, Tel Aviv, Israel Sourasky Tel AvivMed Ctr Tel Aviv Israel Dept Surg A, Tel Aviv, Israel
Titolo Testata:
VIRAL IMMUNOLOGY
fascicolo: 3, volume: 11, anno: 1998,
pagine: 137 - 145
SICI:
0882-8245(1998)11:3<137:CAOIIV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; PROTEIN-KINASE; SIALIC-ACID; ACTIVATION; RECEPTOR; PHOSPHATASE; INDUCTION; INFECTION; PATHWAYS; CD45;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenthal, A Sourasky Tel Aviv Med Ctr, Inst Pathol, Weizman St 6, Tel Aviv, Israel Sourasky Tel Aviv Med Ctr Weizman St 6 Tel Aviv Israel rael
Citazione:
A. Eisenthal et al., "Costimulatory activity of inactivated influenza virus in response of humanperipheral blood mononuclear cells to phytohemagglutinin A and anti-CD3 antibody", VIRAL IMMUN, 11(3), 1998, pp. 137-145

Abstract

We tested the effect of inactivated influenza A virus on the response of human T lymphocytes to several stimuli, Our results demonstrate that the response to both phytohemagglutinin A (PHA) and anti-CD3 was substantially enhanced by pre-exposure of peripheral blood mononuclear cells (PBMC) to heat-inactivated viral particles, whereas no effect was noted on the proliferative response of PBMC to IL-2, In addition to cell proliferation, exposure ofPBMC to viral particles increased the secretion of interferon (IFN)-gamma during stimulation with anti-CD3 antibody and PHA, The costimulatory effectof influenza A virus was reduced by 40% in the presence of 0.1 mM sialic acid. The possible mechanisms involved in the costimulatory effects of influenza A virus are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:08:26