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Titolo:
Tumor necrosis factor-alpha production after esophageal cancer surgery: Differences in the response to lipopolysaccharide stimulation among whole blood, pleural effusion cells, and bronchoalveolar lavage fluid cells
Autore:
Kimura, Y; Yaegashi, Y; Sato, N;
Indirizzi:
Iwate Med Univ, Sch Med, Dept Surg 1, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 1, volume: 29, anno: 1999,
pagine: 10 - 15
SICI:
0941-1291(1999)29:1<10:TNFPAE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTE ELASTASE; INTERLEUKIN-1 RECEPTOR ANTAGONIST; PLASMA-CONCENTRATIONS; SEPSIS SYNDROME; PATHOGENESIS; SHOCK;
Keywords:
tumor necrosis factor-alpha; lipopolysaccharide stimulation; major surgical stress; whole blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, Y Iwate,Med Univ, Sch Med, Dept Surg 1, 19-1 Uchimaru, Morioka, Iwate 0208505 Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 0208505 0208505
Citazione:
Y. Kimura et al., "Tumor necrosis factor-alpha production after esophageal cancer surgery: Differences in the response to lipopolysaccharide stimulation among whole blood, pleural effusion cells, and bronchoalveolar lavage fluid cells", SURG TODAY, 29(1), 1999, pp. 10-15

Abstract

The body's defense mechanism in response to stress may appear to be the sum of activation and suppression. We investigated chronological changes in tumor necrosis factor-alpha. (TNF-alpha) production by local effusion cells and whole blood of esophageal cancer patients who had undergone radical resection, Whole blood, pleural effusion cells, and bronchoalveolar lavage fluid (BALF) cells were obtained from the 20 patients. Whole blood was stimulated with Escherichia coli (1 mu g/ml), Staphylococcus aureus (10 mu g/ml), and lipopolysaccharide (LPS) (1 mu g/ml), and pleural effusion cells and BALF cells were stimulated with LPS; 24-H incubation and TNF-alpha concentration in supernate was measured by enzyme-linked immunosorbent assay (ELISA). Within 3 h after starting the operation, TNF-alpha production in whole blood was significantly (P < 0.05) decreased compared with preoperative value by each stimulation, and this suppression persisted up to day 3, These reductions in postoperative TNF-alpha production correlated with intraoperativehemorrhage, On the other hand, the LPS-induced release of TNF-alpha into pleural effusion cells and BALF cells were markedly increased during the study period. These results indicate that large quantities of cytokines are produced by a second attack, such as infection, in areas where immunocytes accumulate. We believe that the body reacts to surgical stress in a variety of ways. Circulating blood and immunocytes that accumulate in damaged organsare thought to react very differently to stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:34:02