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Titolo:
Rapid decline of cerebral microemboli of arterial origin after intravenousacetylsalicylic acid
Autore:
Goertler, M; Baeumer, M; Kross, R; Blaser, T; Lutze, G; Jost, S; Wallesch, CW;
Indirizzi:
Univ Magdeburg, Dept Neurol, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 rol, D-39120 Magdeburg, Germany Univ Magdeburg, Inst Clin Chem, D-39120 Magdeburg, Germany Univ MagdeburgMagdeburg Germany D-39120 hem, D-39120 Magdeburg, Germany
Titolo Testata:
STROKE
fascicolo: 1, volume: 30, anno: 1999,
pagine: 66 - 69
SICI:
0039-2499(199901)30:1<66:RDOCMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL DOPPLER ULTRASOUND; CAROTID ENDARTERECTOMY; EMBOLIC SIGNALS; VALVES; DIFFERENTIATION; STENOSIS; DISEASE;
Keywords:
antiplatelet agents; carotid artery stenosis; cerebral embolism; stroke; ultrasonography, Doppler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Goertler, M Univ Magdeburg, Dept Neurol, Leipziger Str 44, D-39120 Magdeburg, Germany Univ Magdeburg Leipziger Str 44 Magdeburg Germany D-39120 any
Citazione:
M. Goertler et al., "Rapid decline of cerebral microemboli of arterial origin after intravenousacetylsalicylic acid", STROKE, 30(1), 1999, pp. 66-69

Abstract

Background and Purpose-The present study investigated the influence of theantiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism asdetected by transcranial Doppler sonography (TCD). Methods-Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eight had not received an antiplatelet or anticoagulant medication before TCD, and in 1 patient a preexisting ASA medication (100 mg/d) had not been changed since the onset of stroke symptoms. An initial 1-hour TCD monitoring was extended for an additional 2.5hours after an intravenous bolus injection of 500 mg ASA and was repeated for 1 hour on the following day. Results-Microembolic signals (MES) were detected in all patients only an the symptomatic side. After the ASA bolus injection, a significant drop of the MES rate was found in 7 patients, all without previous medication, starting 30 minutes after the application (mean per hour = 25.1 [range, 6 to 66]versus mean per hour = 6.4 [range, 0 to 14]). In 3 of these patients, platelet aggregation tests were performed that demonstrated normal aggregation before bolus injection and inhibited aggregability as early as 30 minutes after bolus injection. The rate of MES remained unchanged in 1 patient without antiplatelet medication. The ninth patient, who had suffered an ischemicevent on ASA, showed only a transient decrease of MES frequency. Conclusions-In patients with recent stroke of arterial origin, intravenousASA can rapidly reduce cerebral microemboli as detected by TCD. Microemboli might be a useful parameter to monitor early effects of antiplatelet therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:36:51