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Titolo:
Elevated tissue plasminogen activator antigen and stroke risk - The strokeprevention in young women study
Autore:
Macko, RF; Kittner, SJ; Epstein, A; Cox, K; Wozniak, MA; Wityk, RJ; Stern, BJ; Sloan, MA; Sherwin, R; McCarter, RJ; Johnson, CJ; Earley, CJ; Buchholz, DW; Stolley, PD;
Indirizzi:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Neurol, Baltimore, MD 21201 USA Univ Maryland, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA Baltimore Dept Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, Baltimore Dept Vet Affairs Med Ctr Baltimore MD USA c & Clin, Baltimore, Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 Neurol, Baltimore, MD 21218 USA Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 h Med, Dept Neurol, Atlanta, GA 30322 USA
Titolo Testata:
STROKE
fascicolo: 1, volume: 30, anno: 1999,
pagine: 7 - 11
SICI:
0039-2499(199901)30:1<7:ETPAAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC CEREBROVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; FIBRINOLYTIC-ACTIVITY; ANGINA-PECTORIS; PAI-1 COMPLEX; T-PA; PLASMA; INHIBITOR-1; FIBRINOGEN; ADULTS;
Keywords:
cerebral infarction; fibrinolysis; risk factors; young adults; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Macko, RF UnivAMaryland, Sch Med, Dept Neurol, 22 S Greene St, Baltimore, MD 21201 US Univ Maryland 22 S Greene St Baltimore MD USA 21201 MD 21201 US
Citazione:
R.F. Macko et al., "Elevated tissue plasminogen activator antigen and stroke risk - The strokeprevention in young women study", STROKE, 30(1), 1999, pp. 7-11

Abstract

Background and Purpose-Abnormalities in endogenous fibrinolysis are associated with an increased risk for stroke in men and older adults. We tested the hypothesis that elevated plasma tissue plasminogen activator (tPA) antigen, a marker for impaired endogenous fibrinolysis, is an independent risk factor for stroke in young women. Methods-Subjects were 59 nondiabetic females ages 15 to 44 years with cerebral infarction from the Baltimore-Washington area and 97 control subjects frequency-matched for age who were recruited by random-digit dialing from the same geographic area. A history of cerebrovascular disease risk factors was obtained by face-to-face interview. Plasma tPA antigen was measured by enzyme-linked immunosorbent assay. Results-Mean plasma tPA antigen levels were significantly higher in strokepatients than control subjects (4.80 +/- 4.18 versus 3.23 +/- 3.67 ng/mL; P = 0.015). After adjustment for age, hypertension, cigarette smoking, bodymass index, and ischemic heart disease, there was a dose-response association between tPA antigen and stroke with a 3.9-fold odds ratio of stroke (95% CI, 1.2 to 12.4; P = 0.03) for the upper quartile (>4.9 ng/mL) of tPA antigen compared with the lowest quartile. The dose-response relationship between tPA antigen and stroke was equally present in white and nonwhite women,and further adjustment for total and HDL cholesterol levels only modestly attenuated this association. Conclusions-This population-based case-control study shows that elevated plasma tPA antigen level is independently associated with an increased risk for ischemic stroke in nondiabetic females 15 to 44 years of age. These findings support the hypothesis that impaired endogenous fibrinolysis is an important risk factor for stroke in young women.

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Documento generato il 29/11/20 alle ore 00:35:52