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Titolo:
Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats
Autore:
Hirafuji, M; Ebihara, T; Kawahara, F; Nezu, A;
Indirizzi:
Hlthidoi Univ Hokkaido, Fac Pharmaceut Sci, Dept Pharmacol, Ishikari, Hokka Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 l, Ishikari, Hokka HlthHokkaidov Hokkaido, Fac Pharmaceut Sci, Dept Clin Pharmacol, Ishikari,Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 armacol, Ishikari, Hlth3,ci Univ Hokkaido, Sch Dent, Dept Pharmacol, Ishikari, Hokkaido 061029 Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 i, Hokkaido 061029
Titolo Testata:
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
fascicolo: 1, volume: 102, anno: 1998,
pagine: 29 - 42
SICI:
1078-0297(199810)102:1<29:EODAOI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; FISH OIL; ANGIOTENSIN-II; EICOSAPENTAENOIC ACID; BLOOD-PRESSURE; NORADRENALINE; RESPONSES; HYPERTROPHY; HYPERPLASIA; INVOLVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hirafuji, M Hlthidoi Univ Hokkaido, Fac Pharmaceut Sci, Dept Pharmacol, Ishikari, Hokka Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 Hokka
Citazione:
M. Hirafuji et al., "Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats", RES COM M P, 102(1), 1998, pp. 29-42

Abstract

The effects of DHA treatment on intracellular Ca2+ dynamics in aortic smooth muscle cells isolated from young stroke-prone spontaneously hypertensiverats (SHRSP) and age-matched normotensive Wistar Kyoto rats (WKY) were investigated. The resting intracellular Ca2+ concentration ([Ca2+]i) before stimulation and the peak [Ca2+]i induced by 5-HT, angiotensin II and depolarizing concentration of KCl were higher in SHRSP than in WKY. When added to the culture medium for 2 days, DHA at a concentration of 30 mu M significantly suppressed the peak [Ca2+]i induced by these stimulants in aortic smoothmuscle cells isolated from WKY, whereas smooth muscle cells of SHRSP were refractory to the suppression. DHA had no suppressive effect on the 5-HT-induced increase in the inositol triphosphate production. The present study indicates that DHA can suppress receptor-mediated Ca2+ influx, at least, through the voltage-dependent channel, in vascular smooth muscle cells. Since the intracellular Ca2+ plays an important role in regulating vascular tone,the suppressive effect of DHA on [Ca2+]i in vascular smooth muscle cells may be contributed to the beneficial properties of DHA on cardiovascular disorders. The precise mechanisms of action remain to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:30:05