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Titolo:
Plasma glicentin in diabetic and gastrectomized patients
Autore:
Naito, H; Ohneda, A; Kojima, R; Sato, T; Sasaki, K; Funayama, Y; Fukushima, K; Shibata, C; Matsuno, S; Sasaki, I;
Indirizzi:
Tohoku Univ, Sch Med, Dept Surg 1, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Senen Gen Hosp, Tagajo, Miyagi 9850842, Japan Senen Gen Hosp Tagajo Miyagi Japan 9850842 Tagajo, Miyagi 9850842, Japan NissinJapanr Milling Co Ltd, Pharmaceut Res Lab, Oimachi, Saitama 3650045,Nissin Flour Milling Co Ltd Oimachi Saitama Japan 3650045 aitama 3650045,
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1, volume: 79, anno: 1999,
pagine: 55 - 61
SICI:
0167-0115(19990101)79:1<55:PGIDAG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; HUMAN SMALL-INTESTINE; REACTIVE HYPOGLYCEMIA; RENAL-FAILURE; PORCINE; PROGLUCAGON; PURIFICATION; CONTAINS; PRODUCTS; PANCREAS;
Keywords:
glicentin; ELISA; oral glucose; gastrectomy; diabetes mellitus; short bowel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Naito, H Tohoku Univ, Sch Med, Dept Surg 1, Aoba Ku, 1-1 Seiryomachi, Sendai, Miyagi Tohoku Univ 1-1 Seiryomachi Sendai Miyagi Japan 9808574 i, Miyagi
Citazione:
H. Naito et al., "Plasma glicentin in diabetic and gastrectomized patients", REGUL PEPT, 79(1), 1999, pp. 55-61

Abstract

Recent successful synthesis of human glicentin prompted us to establish animmunoassay method for determination of human glicentin in plasma. Human glicentin in plasma was measured using a newly developed sandwich ELISA. Themean fasting levels of human glicentin were 18.6+/-2.4 and 19.7+/-2.1 pM in normal subjects and diabetic patients, respectively. In diabetic patientswith renal failure, plasma glicentin was elevated, exceeding 100 pM. In normal subjects, plasma glicentin increased to a peak level of about 130 pM at 60 min after an oral glucose load, and then decreased. In patients who underwent gastrectomy, plasma glicentin rapidly increased to a peak of about 300 pM at 30 min after oral glucose load. In a patient with short bowel syndrome plasma glicentin did not change following an oral glucose load. Theseresults correspond with previous findings for gut glucagon-like immunoreactive materials (GLI) or enteroglucagon. We conclude that glicentin is secreted from the small intestine in response to intraluminal glucose stimulation in humans. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:09:17