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Titolo:
Angiotensin II: a reproductive hormone too?
Autore:
Speth, RC; Daubert, DL; Grove, KL;
Indirizzi:
Washingtonhysiol,Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & P Washington State Univ Pullman WA USA 99164 & Comparat Anat Pharmacol & P Oregon Hlth Sci Univ, Oregon Reg Primate Res Ctr, Beaverton, OR 97005 USA Oregon Hlth Sci Univ Beaverton OR USA 97005 Ctr, Beaverton, OR 97005 USA
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1, volume: 79, anno: 1999,
pagine: 25 - 40
SICI:
0167-0115(19990101)79:1<25:AIARHT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITOR; OVARIAN FOLLICULAR-FLUID; GONADOTROPIN-RELEASING-HORMONE; LUTEINIZED GRANULOSA-CELLS; RENIN GENE-EXPRESSION; DIRECT OBLIGATE ROLE; RABBIT VAS-DEFERENS; RAT EPIDIDYMIS; MESSENGER-RNA; BLOOD-PRESSURE;
Keywords:
renin-angiotensin system (RAS); angiotensin II (Ang II); renin; prorenin; angiotensinogen (AON); angiotensin-converting enzyme (ACE); angiotensin II receptors; AT-1 angiotensin II receptor subtype (AT-1); AT-2 angiotensin II receptor subtype (AT-2); ovary; uterus; fallopian tube; cervix; testis; epididymis; vas deferens; spermatozoa;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
151
Recensione:
Indirizzi per estratti:
Indirizzo: Speth, RC Washingtonhysiol,Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & P Washington State Univ Pullman WA USA 99164 t Anat Pharmacol & P
Citazione:
R.C. Speth et al., "Angiotensin II: a reproductive hormone too?", REGUL PEPT, 79(1), 1999, pp. 25-40

Abstract

It has long been known that angiotensin II (Ang II) can affect reproductive tissues such as the uterus. However, the existence of a local renin-angiotensin system (RAS) in female as well as male reproductive tissues is a relatively recent observation. Of great interest is the discovery that all components of the RAS are present in the ovary, that the ovary secretes components of the RAS into the bloodstream, and that the ovary itself is responsive to Ang II. Recent studies suggest that the primary role of Ang II in theovary is to cause atresia in non-ovulatory follicles; however, there is also compelling data to suggest that Ang II facilitates ovulation. Male reproductive structures also contain all of the components of the RAS, gonadotropins regulate the activity of these components, and these tissues have Ang II receptors. Of great interest is the expression of testis-specific angiotensin-converting enzyme (ACE), which is located on germ cells. Recent studies using gene knock-out techniques indicate that testis ACE plays an important role in male fertility. However, the overall significance of the RAS for normal reproductive function remains questionable. There is now a body ofevidence implicating the RAS in pathophysiologies associated with reproductive function, which gives rise to the possibility that drugs acting on theRAS might ameliorate some of these disorders. Considerable work remains todetermine the role of Ang II in reproductive functions. (C) 1999 Publishedby Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:31:27