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Titolo:
Effect of nociceptin on alcohol intake in alcohol preferring rats
Autore:
Ciccocioppo, R; Panocka, I; Polidori, C; Regoli, D; Massi, M;
Indirizzi:
Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, Italy UnivCamerino Camerino Italy I-62032 & Expt Med, I-62032 Camerino, Italy Polishrokow,Sci, Inst Genet & Anim Breeding, Dept Behav Physiol, PL-05551 M Polish Acad Sci Mrokow Poland PL-05551 g, Dept Behav Physiol, PL-05551 M Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 harmacol Sect, I-44100 Ferrara, Italy
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 141, anno: 1999,
pagine: 220 - 224
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHAN OPIOID RECEPTOR; FQ; DEPENDENCE; DRINKING; NEUROPEPTIDE; NALTREXONE; AGONIST;
Keywords:
nociceptin; orphanin FQ; alcohol intake; Marchigian Sardinian alcohol-preferring rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Massi, M Univino,erino, Dept Pharmacol Sci & Expt Med, Via Scalzino 3, I-62032 Camer Univ Camerino Via Scalzino 3 Camerino Italy I-62032 -62032 Camer
Citazione:
R. Ciccocioppo et al., "Effect of nociceptin on alcohol intake in alcohol preferring rats", PSYCHOPHAR, 141(2), 1999, pp. 220-224

Abstract

The present study investigated the effect of nociceptin (NC). the endogenous ligand of the opioid-like orphan receptor ORL1, on ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Acuteintracerebroventricular (ICV) injection of 250 or 500 ng/rat of NC, just before access to 10% ethanol (offered 2 h/day), significantly increased ethanol intake. Subchronic (7 days) ICV injection of 500 ng/rat of NC, given just before access to 10% ethanol (for 30 min/day), resulted in a progressivedecrease in ethanol consumption. After the end of NC treatment. rats progressively recovered their usual ethanol intake. When NC, 500 or 1000 ng/rat,was tested versus the effect of ethanol in the place conditioning paradigm, NC significantly reduced the increase in time spent in the ethanol-pairedcompartment after conditioning. This finding suggests that NC reduces the rewarding properties of ethanol in msP rats; thus, they may respond to the acute NC administration by increasing their ethanol intake in an attempt toachieve the usual reinforcing effect of ethanol, whereas subchronic NC treatment may result in extinction of ethanol drinking. The results of the present study suggest that the brain NC mechanisms may represent an interesting target of pharmacological interventions for the treatment of alcoholism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:07:28