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Titolo:
In vivo I-123 IBZM SPECT imaging of striatal dopamine-2 receptor occupancyin schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol
Autore:
Tauscher, J; Kufferle, B; Asenbaum, S; Fischer, P; Pezawas, L; Barnas, C; Tauscher-Wisniewski, S; Brucke, T; Kasper, S;
Indirizzi:
Univ Vienna, Dept Gen Phys, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Gen Phys, A-1090 Vienna, Austria Univ Vienna, Dept Clin Neurol, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 pt Clin Neurol, A-1090 Vienna, Austria Wilhelminenspital Stadt Wien, A-1171 Vienna, Austria Wilhelminenspital Stadt Wien Vienna Austria A-1171 -1171 Vienna, Austria
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 141, anno: 1999,
pagine: 175 - 181
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC OLANZAPINE; POSITRON EMISSION TOMOGRAPHY; DOUBLE-BLIND; IN-VIVO; PET; D-2; NEUROLEPTICS; BINDING; RISPERIDONE; TRIAL;
Keywords:
olanzapine; dopamine D-2 receptor; I-123 IBZM; SPECT; atypical antipsychotic drug;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tauscher, J Univ Vienna, Dept Gen Phys, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 tria
Citazione:
J. Tauscher et al., "In vivo I-123 IBZM SPECT imaging of striatal dopamine-2 receptor occupancyin schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol", PSYCHOPHAR, 141(2), 1999, pp. 175-181

Abstract

We investigated the degree of striatal dopamine-2 (D-2) receptor occupancyin six schizophrenic patients receiving clinically effective antipsychotictreatment with olanzapine 10-25 mg/day in comparison to patients treated with clozapine 300-600 mg/day (n = 6) or haloperidol 5-20 mg/day (n = 10). I-123 Iodobenzamide (IBZM) and single photon emission computerized tomography (SPECT) were used for the visualization of striatal D-2 receptors. For the quantification of striatal D-2 receptor occupancy, striatal IBZM binding in patients treated with antipsychotics was compared to that in untreated healthy controls (n = 8) reported earlier. Olanzapine led to a mean striatalD-2 receptor occupancy rate of 75% (range 63-85). Haloperidol-treated patients showed dose-dependently (Pearson r = 0.64; P < 0.05) a significantly higher (P < 0.05) mean occupancy rate of 84% (range 67-94). During clozapinetreatment, the mean D-2 receptor occupancy of 33% (range < 20-49) was significantly lower than with olanzapine (P < 0.005). The higher striatal D-2 receptor occupancy of haloperidol was correlated with the incidence and severity of extrapyramidal motor side-effects (EPS). No clinical relevant EPS occurred during treatment with olanzapine or clozapine. There was no correlation between the degree of striatal D-2 receptor occupancy and clinical improvement.

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Documento generato il 17/09/19 alle ore 22:47:39