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Titolo:
Repeated neonatal maternal separation alters intravenous cocaine self-administration in adult rats
Autore:
Matthews, K; Robbins, TW; Everitt, BJ; Caine, SB;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 141, anno: 1999,
pagine: 123 - 134
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL RESPONSES; NUCLEUS-ACCUMBENS; INDIVIDUAL VULNERABILITY; DIFFERENT SCHEDULES; DOPAMINE-RECEPTORS; LOCOMOTOR RESPONSE; MESSENGER-RNA; D-AMPHETAMINE; STRESS;
Keywords:
maternal separation; cocaine; intravenous self-administration; mesolimbic dopamine; reward; eticlopride; SCH 23390;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, K Univandndee, Ninewells Hosp & Med Sch, Dept Psychiat, Dundee DD1 9SY, Scotl Univ Dundee Dundee Scotland DD1 9SY t, Dundee DD1 9SY, Scotl
Citazione:
K. Matthews et al., "Repeated neonatal maternal separation alters intravenous cocaine self-administration in adult rats", PSYCHOPHAR, 141(2), 1999, pp. 123-134

Abstract

Behavioural responses to psychostimulant drugs can be profoundly affected by early environmental influences. The aim of this study was to describe the effects of repeated brief separations of rat pups from their dams during the early neonatal period on cocaine self-administration behaviour as adults. Lister hooded rats exposed to a repeated maternal separation procedure (REMS) showed altered acquisition and maintenance of cocaine self-administration as adults, the effects being dose and gender-dependent. Overall, the patterns of acquisition of self-administration across three doses of cocaine(0.05, 0.08 and 0.5 mg/injection) suggested a rightward shift in the acquisition dose-effect functions for the REMS animals relative to control animals. At 0.05 mg/injection, there was a retarded acquisition of cocaine self-administration in male and female neonatally separated rats. At 0.08 mg/injection there was a facilitated acquisition in female neonatally separated subjects. After establishment of stable self-administration of the training dose, in the same cohort of subjects, rightward and downward shifts in the cocaine self-administration dose-effect functions were determined for female and male REMS subjects, respectively, relative to their controls. The dose-effect function for both female groups was shifted to the left of that ofthe respective male groups, although the lighter body weights of the females meant that they administered a higher unit dose per unit body weight than the males. Whereas male REMS subjects tended to self-administer less cocaine than the controls at the dose eliciting maximal responding (0.03 mg/injection) and to make fewer lever responses overall at each dose tested, female REMS subjects self-administered significantly more cocaine than their respective controls at a dose of 0.03 mg/injection. There was no differentialsensitivity to the rate-altering effects of the selective dopamine D-2 receptor antagonist, eticlopride, or to the selective dopamine D-1 receptor antagonist, SCH 23390. These data provide further evidence that altered earlyenvironment affects drug-taking behaviour in a developmentally specific and gender-specific manner, with the effects of neonatal separation contrasting with previously published data on the effects of post-weaning isolation rearing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:56:57