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Titolo:
IgG subclass antibody responses to birch pollen in sibling pairs discordant for atopy
Autore:
Harfast, B; van Hage-Hamsten, M; Lilja, G;
Indirizzi:
Karolinska Hosp, Dept Lab Med, Div Clin Immunol, S-17176 Stockholm, SwedenKarolinska Hosp Stockholm Sweden S-17176 unol, S-17176 Stockholm, Sweden Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden Karolinska Inst Stockholm Sweden achs Childrens Hosp, Stockholm, Sweden
Titolo Testata:
PEDIATRIC ALLERGY AND IMMUNOLOGY
fascicolo: 4, volume: 9, anno: 1998,
pagine: 208 - 214
SICI:
0905-6157(199811)9:4<208:ISARTB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGEN; LYMPHOCYTES; SPECIFICITY; DIAGNOSIS; ASTHMA; ELISA;
Keywords:
birch pollen allergens; atopy; Bet v 1; allergen specific IgG antibodies; children; subclasses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Harfast, B Karolinska Hosp, Dept Lab Med, Div Clin Immunol, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 76 Stockholm, Sweden
Citazione:
B. Harfast et al., "IgG subclass antibody responses to birch pollen in sibling pairs discordant for atopy", PEDIAT A IM, 9(4), 1998, pp. 208-214

Abstract

Birch pollen allergen specific IgG and IgE antibodies were analysed in thesera of fourteen sibling pairs discordant for atopy. In addition, eight unrelated children free of atopic disease were included in the study. The presence of Bet v 1 specific antibodies in the sera were analysed by an immunoblotting assay. All but one (13/14) of the atopic children had detectable anti-Bet v 1 antibodies of the IgG1 and IgG4 subclasses. The child lacking IgG1 and IgG4 antibodies to Bet v 1 was the only allergic child lacking IgE to Bet v 1. In contrast, only one of the non-atopic siblings (1/14) displayed detectable IgG1 antibodies to Bet v 1. Furthermore, among the non-atopicsiblings none (0/14), had detectable IgG4 antibodies to Bet v 1. In the unrelated control group no detectable IgG1 or IgG4 anti-Bet v 1 were detected(0/8). Thus of the non-atopic children only one out of 22 children displayed IgG1 anti-Bet v 1 antibodies. Taken together, it appears that the non-atopic children in general have no/low allergen specific IgG to birch pollen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 03:38:49