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Titolo:
Reduction of serum cholesterol by soy proteins: clinical experience and potential molecular mechanisms
Autore:
Sirtori, CR; Lovati, MR; Manzoni, C; Gianazza, E; Bondioli, A; Staels, B; Auwerx, J;
Indirizzi:
Univ Milan, Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan, Ctr E Grossi Paoletti, I-20133 Milan, Italy Univ Milan MilanItaly I-20133 r E Grossi Paoletti, I-20133 Milan, Italy
Titolo Testata:
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
fascicolo: 5, volume: 8, anno: 1998,
pagine: 334 - 340
SICI:
0939-4753(199810)8:5<334:ROSCBS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FECAL BILE-ACIDS; SOYBEAN-PROTEIN; PLASMA-LIPIDS; HYPERCHOLESTEROLEMIC PATIENTS; II HYPERLIPOPROTEINEMIA; LIPOPROTEIN RECEPTORS; NEUTRAL STEROLS; DIET; ISOFLAVONES; INHIBITORS;
Keywords:
soy protein; hypercholesterolaemia; fibres; isoflavones; 7S globulins; 11S globulins; LDL receptors; soy peptides;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Sirtori, CR Univ Milan, Inst Pharmacol Sci, Via Balzaretti 9, I-20133 Milan, Italy Univ Milan Via Balzaretti 9 Milan Italy I-20133 Milan, Italy
Citazione:
C.R. Sirtori et al., "Reduction of serum cholesterol by soy proteins: clinical experience and potential molecular mechanisms", NUTR MET CA, 8(5), 1998, pp. 334-340

Abstract

The major components of soybean flour (ie, proteins, fibres, and isoflavones) have been investigated as possibly responsible for the cholesterol-lowering effects of soy-based diets. The evidence for and against the involvement of each component is reviewed. A role for indigestible components has long been ruled out because soybean saponins are unable to bind neutral sterols and bile acids and increase their faecal elimination. A direct role for soy isoflavones seems to be suggested by experiments in monkeys fed with control vs ethanol-treated soybeans. However, in humans, plasma cholesterol reduction has been obtained with protein preparations virtually devoid of isoflavones. Moreover, the major soybean isoflavone, genistein, being an inhibitor of tyrosine kinase, is expected to antagonize the activation of low density lipoprotein (LDL)-receptors, whose up-regulation has been repeatedlyshown to be involved in the mechanism of increased LDL degradation by the ii ver induced by soy and possibly resulting in hypocholesterolaemia. The LDL receptor stimulatory effect will probably be traced to 7S, one of the major soybean proteins, and specifically to one of its subunits, the alpha chain, which is more effectively catabolised by liver cells than the beta chain. To positively establish proteins as the active components of soybean-based diets, ongoing studies aim to link intracellular catabolism in vitro with the physiological pathway of intestinal digestion in vivo, and especially to determine the possible presence in serum of undegraded or partially degraded 7S-derived peptide fragments. (C) 1998, Medikal Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:20:38