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Titolo:
EFFECT OF RENAL-ARTERY STENTING ON PROGRESSION OF RENOVASCULAR RENAL-FAILURE
Autore:
HARDEN PN; MACLEOD MJ; RODGER RSC; BAXTER GM; CONNELL JMC; DOMINICZAK AF; JUNOR BJR; BRIGGS JD; MOSS JG;
Indirizzi:
N STAFFORDSHIRE ROYAL INFIRM,DEPT NEPHROL STOKE ON TRENT ST4 7LN STAFFS ENGLAND UNIV GLASGOW,WESTERN INFIRM,RENAL UNIT GLASGOW G11 6NT LANARK SCOTLAND UNIV GLASGOW,WESTERN INFIRM,DEPT MED & RADIOL GLASGOW G11 6NT LANARK SCOTLAND
Titolo Testata:
Lancet
fascicolo: 9059, volume: 349, anno: 1997,
pagine: 1133 - 1136
SICI:
0140-6736(1997)349:9059<1133:EORSOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
WALLSTENT ENDOPROSTHESIS; DISEASE; STENOSIS; ANGIOPLASTY; PLACEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Harden et al., "EFFECT OF RENAL-ARTERY STENTING ON PROGRESSION OF RENOVASCULAR RENAL-FAILURE", Lancet, 349(9059), 1997, pp. 1133-1136

Abstract

Background Placement of renal-artery stents has a high technical success rate in atherosclerotic renovascular disease, but little is known about the clinical benefits of the procedure. We monitored renal function serially before and after stent insertion in patients with renovascular renal failure. Methods Renal function was assessed before and after stent placement by means of serial serum creatinine Values in 32 patients with atherosclerotic renal-artery stenosis. The effect on the progression of renal failure was analysed in 23 patients by comparisonof the reciprocal slopes of serum creatinine versus time plots beforeand after stent placement. Findings 33 transluminal stents were placed in 32 patients with atherosclerotic renovascular disease. Immediate patency was achieved in all cases; the angiographic restenosis rate at6 months was 12% (n=24). One patient died after a procedure-related haemorrhage. Median diastolic blood pressure was significantly lower after stenting than before (95 [IQR 86-103] vs 87 [81-90] mm Hg; p>0.01)but the requirement for antihypertensive drugs was unchanged. Renal function improved or stabilised in 22 (69%) of the 32 patients. Progression of renal failure was significantly slowed after the procedure; the mean (SE) of the slopes of reciprocal serum creatinine values was -4.34 (0.85) L mu mol(-1) day(-1) before stent placement, and -0.55 (1.0) L mu mol(-1) day(-1) after stent placement (p<0.01, two-sample t test). Interpretation Renal-stent placement in selected patients slows the progression of renovascular renal failure and may delay the need forrenal replacement therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:57:43