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Titolo:
Hepatoprotective effects of garlic during hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene
Autore:
Balasenthil, S; Nagini, S;
Indirizzi:
Annamalaindiav, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, I Annamalai Univ Annamalainagar Tamil Nadu India 608002 8002, Tamil Nadu, I
Titolo Testata:
MEDICAL SCIENCE RESEARCH
fascicolo: 12, volume: 26, anno: 1998,
pagine: 849 - 851
SICI:
0269-8951(199812)26:12<849:HEOGDH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE S-TRANSFERASES; ORGANOSULFUR COMPOUNDS; VITAMIN-E; MICE; GROWTH; RATS; CONSTITUENTS; SELENIUM; EXTRACT; CANCER;
Keywords:
garlic; 7,12-dimethylbenz[a]anthracene; oral cancer; chemoprevention; lipid peroxidation; antioxidants; glutathione; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalaindiav, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, I Annamalai Univ Annamalainagar Tamil Nadu India 608002 l Nadu, I
Citazione:
S. Balasenthil e S. Nagini, "Hepatoprotective effects of garlic during hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene", MED SCI RES, 26(12), 1998, pp. 849-851

Abstract

We have studied the protective effect of garlic (Allium sativum) on hepatic lipid peroxidation and antioxidant status during buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) in Syrian male hamsters. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx) and glutathione-S-transferase (GST) and a reduction in the glutathione (GSH) level. Administration of garlic extract significantly lowered lipid peroxidation and enhanced the levels of antioxidants. We speculate that garlic exerts its anticarcinogenic effects by influencing hepatic biotransformation enzymes and antioxidants. Med Sci Res 26:849-851. (C) 1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:44:38