Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FATTY-ACID COMPOSITION AND CD36 EXPRESSION IN BREAST ADIPOSE-TISSUE OF PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN
Autore:
ABBADIA Z; VERICEL E; MATHEVET P; BERTIN N; PANAYE G; FRAPPART L;
Indirizzi:
HOP EDOUARD HERRIOT,CNRS,UMR 5641,BAT 10 F-69437 LYON 03 FRANCE HOP EDOUARD HERRIOT,CNRS,UMR 5641 F-69437 LYON 03 FRANCE INSA 406,INSERM U352,CHIM BIOL LAB F-69621 VILLEURBANNE FRANCE HOP EDOUARD HERRIOT,CTR COMMUN CYTOMETRIE FLUX F-69437 LYON 03 FRANCE
Titolo Testata:
Anticancer research
fascicolo: 2A, volume: 17, anno: 1997,
pagine: 1217 - 1221
SICI:
0250-7005(1997)17:2A<1217:FCACEI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY EPITHELIAL-CELLS; MG-63 OSTEOBLASTIC CELLS; MEMBRANE-PROTEIN; LINOLEIC-ACID; THROMBOSPONDIN TSP1; GROWTH; TUMOR; CANCER; METASTASIS; MILK;
Keywords:
CD36 FATTY ACID; ADIPOCYTE; HUMAN BREAST CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
Z. Abbadia et al., "FATTY-ACID COMPOSITION AND CD36 EXPRESSION IN BREAST ADIPOSE-TISSUE OF PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN", Anticancer research, 17(2A), 1997, pp. 1217-1221

Abstract

The mammary gland is an organ under complex hormonal and developmental regulation. Among the mediators involved in this process are polypeptides, steroid hormones and certain lipids and their metabolites. The fatty acid content of the breast adipocytes is investigated because ofthe importance of their role in the proliferation and differentiationof the breast epithelial cells. Materials and Methods: To address thehypothesis that polyunsaturated acid might be a risk factor for breast cancer; we examined the association between arachidonic acid (20:4n-6) and menopausal status in the women using lipid extraction fr om isolated human adipocytes and CD36 detection on a FACS flow cytometer. Results: Compared with the related triglycerides, phospholipids in postmenopausal women contained a higher proportion of polyunsaturated fattyacids like arachidonic acid, a precursor of eicosanoids, required formany physiological roles in reproduction and implicated in the proliferation of several cell types. In order to determine the mechanisms explaining the difference in the fatty acid and long-chain fatty acid composition, we have studied the relationship between CD 36 protein and menopausal status. Menopause in women seemed to be associated with a diminution of the amount of CD 36 protein of adipocytes (48.82 +/- 3.54% versus 20.01 +/- 0.04 %) and also associated with the increased percentage of arachidonic acid observed in postmenopausal women. Our dataand others led us to conclude that the variation in the composition of fatty acids can act directly on the phenomena of growth and differentiation of mammary epithelial cells and the variation in CD 36 may acteither on the transport of fatty acids or on the transduction of the signal responsible for the stimulation of enzymes catalysing the conversion of arachidonic acid into different metabolites. These two phenomena could influence the risk of breast cancer in pre- and postmenopausal women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:00:17