Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of corticotropin-releasing factor in depression and anxiety disorders
Autore:
Arborelius, L; Owens, MJ; Plotsky, PM; Nemeroff, CB;
Indirizzi:
Emorytlanta,Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, A Emory Univ Atlanta GA USA 30322 & Behav Sci, Lab Neuropsychopharmacol, A Emoryta,iv, Sch Med, Dept Psychiat & Behav Sci, Lab Stress Neurobiol, Atlan Emory Univ Atlanta GA USA 30322 & Behav Sci, Lab Stress Neurobiol, Atlan
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 1, volume: 160, anno: 1999,
pagine: 1 - 12
SICI:
0022-0795(199901)160:1<1:TROCFI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; PITUITARY-ADRENAL AXIS; OBSESSIVE-COMPULSIVE DISORDER; FACTOR-LIKE IMMUNOREACTIVITY; CEREBROSPINAL-FLUID CONCENTRATIONS; MAJOR DEPRESSION; LOCUS-COERULEUS; RAT-BRAIN; CUSHINGS-DISEASE; MESSENGER-RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Nemeroff, CB Emoryuitev, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, S Emory Univ Suite 4000,WMRB,1639 Pierce Dr Atlanta GA USA 30322
Citazione:
L. Arborelius et al., "The role of corticotropin-releasing factor in depression and anxiety disorders", J ENDOCR, 160(1), 1999, pp. 1-12

Abstract

Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the evidence suggesting that CRF is hypersecreted from hypothalamic as well as from extrahypothalamic neurons in depression, resulting in hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevations of cerebrospinal fluid (CSF) concentrations of CRF. This increase in CRF: neuronal activity is also believed to mediate certain of the behavioral symptoms of depression involving sleep and appetite disturbances, reduced libido, and psychomotor changes. The hyperactivity of CRF neuronal systems appears to be a state marker for depression because HPA axis hyperactivity normalizes following successful antidepressant treatment. Similar biochemicaland behavioral findings have been observed in adult rats and monkeys that have been subjected to early-life stress. In contrast, clinical studies have not revealed any consistent changes in CSF CRF concentrations in patientswith anxiety disorders; however, preclinical findings strongly implicate arole for CRF in the pathophysiology of certain anxiety disorders, probablythrough its effects on central noradrenergic systems. The findings reviewed here support the hypothesis that CRF receptor antagonists may represent anovel class of antidepressants and/or anxiolytics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:21:52