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Titolo:
Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs
Autore:
Resell, C; Segales, J; Plana-Duran, J; Balasch, M; Rodriguez-Arrioja, GM; Kennedy, S; Allan, GM; McNeilly, F; Latimer, KS; Domingo, M;
Indirizzi:
UAB, Fac Vet, UD Anat Patol, Barcelona 08193, Spain UAB Barcelona Spain 08193 Fac Vet, UD Anat Patol, Barcelona 08193, Spain Fort Dodge Vet SA, Crta Camprodon, Vall de Bianya 17813, Girona, Spain Fort Dodge Vet SA Vall de Bianya Girona Spain 17813 17813, Girona, Spain Dept Agr No Ireland, Vet Sci Div, Belfast BT9 5PX, Antrim, North Ireland Dept Agr No Ireland Belfast Antrim North Ireland BT9 5PX m, North Ireland Univ Georgia, Coll Vet Med, Dept Vet Pathol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 d, Dept Vet Pathol, Athens, GA 30602 USA
Titolo Testata:
JOURNAL OF COMPARATIVE PATHOLOGY
fascicolo: 1, volume: 120, anno: 1999,
pagine: 59 - 78
SICI:
0021-9975(199901)120:1<59:PIAIHS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNDROME VIRUS; PORCINE CIRCOVIRUS; INFECTION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Resell, C UAB, Fac Vet, UD Anat Patol, Barcelona 08193, Spain UAB Barcelona Spain 08193 D Anat Patol, Barcelona 08193, Spain
Citazione:
C. Resell et al., "Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs", J COMP PATH, 120(1), 1999, pp. 59-78

Abstract

Fifteen pigs from five farms on which there had been a previous clinical and histopathological diagnosis of postweaning multisystemic wasting syndrome (PMWS) were investigated. At necropsy, enlargement of lymph nodes was themost obvious lesion; other lesions were non-collapsed lungs, ulceration ofthe gastric pars oesophagica, and cranioventral pulmonary consolidation. Microscopical lesions attributable to PMWS were found in lymphoid organs (including lymph nodes, tonsil, Peyer's patches and spleen), liver, kidney andlungs. Varying degrees of lymphocellular depletion, affecting both lymphoid follicles and parafollicular zones, and progressive multifocal to diffuseinfiltration of lymphoid tissue by large histiocytic cells were the characteristic lesions. Syncytial cells were seen frequently, especially in lymphoid organs. A prominent finding was the presence of sharply demarcated, spherical, basophilic, cytoplasmic inclusions in histiocytic cells. The lymphoid lesions were suggestive of immunosuppression. Non-lymphoid lesions included interstitial pneumonia, periportal mononuclear inflammatory infiltration of the liver in varying degrees, and interstitial nephritis. Porcine circovirus (PCV) antigen and nucleic acid were regularly found in lymphoid organs, lung, liver and, to a lesser degree, kidney. Target cells for PCV replication included monocyte/macrophage lineage and antigen-presenting cells. To a lesser extent, epithelial cells such as renal tubular, bronchial and bronchiolar cells, endothelial cells, hepatocytes and lymphocytes were also labelled. One pig did not show PCV nucleic acid; sequence differences among different viral isolates are discussed as the probable cause of this lack of labelling by the in-situ hybridization PCV-specific probe. (C) 1999 W.B. Saunders Company Limited.

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Documento generato il 29/03/20 alle ore 14:49:31