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Titolo:
Neuropsychological and neuroimaging correlates in corticobasal degeneration
Autore:
Frasson, E; Moretto, G; Beltramello, A; Smania, N; Pampanin, M; Stegagno, C; Tanel, R; Rizzuto, N;
Indirizzi:
Univ Verona, Policlin Borgo Roma, Dept Neurol & Visual Sci, I-37134 Verona, Univ Verona Verona Italy I-37134 pt Neurol & Visual Sci, I-37134 Verona, Univ Verona, Policlin Borgo Roma, Inst Radiol, I-37134 Verona, Italy Univ Verona Verona Italy I-37134 oma, Inst Radiol, I-37134 Verona, Italy Univ Verona, Policlin Borgo Roma, Rehabil Unit, I-37134 Verona, Italy UnivVerona Verona Italy I-37134 ma, Rehabil Unit, I-37134 Verona, Italy
Titolo Testata:
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES
fascicolo: 5, volume: 19, anno: 1998,
pagine: 321 - 328
SICI:
0392-0461(199810)19:5<321:NANCIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIONIC DEGENERATION; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL BLOOD-FLOW; NEURONAL ACHROMASIA; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; APRAXIA; CIRCUITS; MOTOR; PET;
Keywords:
corticobasal degeneration; neuropsychology; apraxia; MRI; PET; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Moretto, G Univ Verona, Policlin Borgo Roma, Dept Neurol & Visual Sci, I-37134 Verona, Univ Verona Verona Italy I-37134 Visual Sci, I-37134 Verona,
Citazione:
E. Frasson et al., "Neuropsychological and neuroimaging correlates in corticobasal degeneration", ITAL J NEUR, 19(5), 1998, pp. 321-328

Abstract

The aim of this study was to correlate neuropsychological and neuroimagingfindings in corticobasal degeneration (CBD). Three patients with clinical criteria for CBD were examined by means of neuropsychological tests, brain magnetic resonance imaging (MRI), and flow and metabolism neuroimaging techniques. Neuropsychological assessment revealed impairment in executive functions, manual dexterity and motor programming with significant asymmetry between upper limbs. Ideomotor and oral apraxia were also detected, and memory deficits were observed in one patient. MRI revealed cortical dilation of the frontal and perirolandic regions, symmetrical in one case and asymmetrical in the other two cases. An increased T2 signal intensity in the posterolateral putamen and substantia nigra ipsilateral to the cortical atrophy was observed in one patient. Asymmetries of both frontal and parietal cortices and basal ganglia were detected in all three patients by 18-fluorodeoxyglucose positron emission tomography; temporal region hypometabolism was associated in one patient. These cortical and subcortical asymmetries were observed in two patients by single photon emission tomography with the tracer technetium Tc 99m hexamethyl propylenamine oxime; cortical asymmetry was observed in only one patient. The results showed that ;functional neuroimagingfindings correlated well with neuropsychological aspects in CBD. Neuroimaging and neuropsychological correlations may contribute toward understandinganatomical and functional abnormalities associated with this neurodegenerative disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:40:47