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Titolo:
The role of early measurement of Nitrogen-13 ammonia uptake for predictingcontractile recovery after acute myocardial infarction
Autore:
Lancellotti, P; Melon, PG; de Landsheere, CM; Degueldre, C; Kulbertus, HE; Pierard, LA;
Indirizzi:
Univ Hosp Liege B35, Div Cardiol, B-4000 Liege, Belgium Univ Hosp Liege B35 Liege Belgium B-4000 Cardiol, B-4000 Liege, Belgium Univ Liege, Cyclotron Res Ctr, Liege, Belgium Univ Liege Liege BelgiumUniv Liege, Cyclotron Res Ctr, Liege, Belgium
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIAC IMAGING
fascicolo: 4, volume: 14, anno: 1998,
pagine: 261 - 267
SICI:
0167-9899(199808)14:4<261:TROEMO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CONTRAST ECHOCARDIOGRAPHY; VIABLE MYOCARDIUM; BLOOD-FLOW; IDENTIFICATION; METABOLISM; VIABILITY; REPERFUSION; PERFUSION; INTEGRITY;
Keywords:
N-13 ammonia; acute myocardial infarction; contractility; echocardiography; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lancellotti, P Univ Hosp Liege B35, Div Cardiol, B-4000 Liege, Belgium Univ Hosp Liege B35 Liege Belgium B-4000 0 Liege, Belgium
Citazione:
P. Lancellotti et al., "The role of early measurement of Nitrogen-13 ammonia uptake for predictingcontractile recovery after acute myocardial infarction", INT J CAR I, 14(4), 1998, pp. 261-267

Abstract

Previous studies have shown that the maintenance of cell membrane integrity and metabolism requires the persistence of residual myocardial blood flow. The purpose of this study was to assess the role of N-13 ammonia positronemission tomographic (PET) imaging performed early after an acute myocardial infarction for predicting functional recovery. Seventeen patients with an acute myocardial infarction were included in the study. Thirteen receivedthrombolytic therapy, 2 underwent immediate angioplasty of the infarct-related artery and 2 were treated with heparin. N-13 ammonia imaging was performed 6 +/- 2 days after the acute event and was followed by elective angioplasty in 13 patients. Using a 16-segment polar map display, regional N-13 ammonia uptake was expressed as a percentage of maximal segmental uptake andclassified as normal (> 63%), moderately reduced (63-50%) and severely reduced (<50%) based on values of tracer uptake obtained from healthy subjects. By echocardiographic assessment of regional wall thickening within 96 hours and at 1 month after the infarct, we examined the relationship between blood flow and functional outcome of myocardial segments in the infarct-related area. Regional wall thickening was graded on a 4-point scale: normal (1), hypokinesia (2), akinesia (3) and dyskinesia (4). Of 77 dyssynergic segments at baseline echocardiographic study, 43 had normal flow, 15 moderatelyreduced flow and 19 severely reduced flow. Segments with N-13 ammonia uptake < 50% demonstrated a significant improvement in wall thickening score atfollow-up (p<0.001), whereas segments with N-13 ammonia uptake <50% showedno improvement in wall thickening scores (p<0.001). The proportion of segments improving contractility by at least 1 score was significantly higher in the group of segments with N-13 ammonia uptake >63%. The predictive valuefor defining functional recovery with segmental N-13 ammonia uptake >63% was 86%. The predictive value for absence of recovery (uptake <50%) was 54%. In conclusion, our data showed that early after an acute myocardial infarction N-13 ammonia imaging provides information regarding functional outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:41:27