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Titolo:
Single- and multiple-trait mapping analysis of linked quantitative trait loci: Some asymptotic analytical approximations
Autore:
Ronin, YI; Korol, AB; Nevo, E;
Indirizzi:
Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel Univ Haifa Haifa Israel IL-31905 fa, Inst Evolut, IL-31905 Haifa, Israel
Titolo Testata:
GENETICS
fascicolo: 1, volume: 151, anno: 1999,
pagine: 387 - 396
SICI:
0016-6731(199901)151:1<387:SAMMAO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARKER LOCI; MAXIMUM-LIKELIHOOD; FLANKING MARKERS; LINKAGE ANALYSIS; LINE CROSSES; EPISTASIS; EVOLUTION; RECOMBINATION; REGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Korol, AB Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel Univ Haifa Haifa Israel IL-31905 volut, IL-31905 Haifa, Israel
Citazione:
Y.I. Ronin et al., "Single- and multiple-trait mapping analysis of linked quantitative trait loci: Some asymptotic analytical approximations", GENETICS, 151(1), 1999, pp. 387-396

Abstract

Estimating the resolution power of mapping analysis of linked quantitativetrait loci (QTL) remains a difficult problem, which has been previously addressed mainly by Monte Carlo simulations. The analytical method of evaluation of the expected LOD developed in this article spreads the "deterministic sampling" approach for the case of two linked QTL for single- and two-trait analysis. Several complicated questions are addressed through this evaluation: the dependence of QTL detection power on the QTL effects, residual correlation between the traits, and the effect of epistatic interaction between the QTL for one or both traits on expected LOD (ELOD), etc. Although this method gives only an asymptotic estimation of ELOD, it allows one to getall approximate assessment of a broad spectrum of mapping situations. A good correspondence was found between the ELODs predicted by the model and LOD values averaged ol er Monte Carlo simulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:11:43