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Titolo:
Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila
Autore:
Comeron, JM; Kreitman, M; Aguade, M;
Indirizzi:
Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 pt Ecol & Evolut, Chicago, IL 60637 USA Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
GENETICS
fascicolo: 1, volume: 151, anno: 1999,
pagine: 239 - 249
SICI:
0016-6731(199901)151:1<239:NSOSSI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CODON USAGE BIAS; ELEMENT COPY NUMBER; ESCHERICHIA-COLI; TRANSLATIONAL ACCURACY; DELETERIOUS MUTATIONS; ENTEROBACTERIAL GENES; BACKGROUND SELECTION; MOLECULAR EVOLUTION; EXPRESSED GENES; TRANSFER-RNAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Comeron, JM Univ Chicago, Dept Ecol & Evolut, 1101 E 57th St, Chicago, IL 60637 USA Univ Chicago 1101 E 57th St Chicago IL USA 60637 IL 60637 USA
Citazione:
J.M. Comeron et al., "Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila", GENETICS, 151(1), 1999, pp. 239-249

Abstract

Evolutionary analysis of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are subject to weak selection at the translation level. Here we show that the effectiveness of natural selection on synonymous sites is strongly correlated with the rate of recombination, in accord with the nearly neutral hypothesis. This correlation, however,is apparent only in genes encoding shore proteins. Long coding regions have both a lower codon bias and higher synonymous substitution rates, suggesting that they are affected less efficiently by selection. Therefore, both the length of the coding region and the recombination rate modulate codon bias. In addition, the data indicate that selection coefficients for synonymous mutations must vary by a minimum of one or two orders of magnitude. Two hypotheses are proposed to explain the relationship among the coding regionlength, the codon bias, and the synonymous divergence and polymorphism levels across the range of recombination rates in Drosophila. The first hypothesis is that selection coefficients on synonymous mutations are inversely related to the total length of the coding region. The second hypothesis proposes that interference among synonymous mutations reduces the efficacy of selection on these mutations. Mle investigated this second hypothesis by carrying our forward simulations of weakly selected mutations in model populations. These simulations show that even with realistic recombination rates, this interference, which we call the "small-scale" Hill-Robertson effect, can have a moderately strong influence on codon bias.

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Documento generato il 04/12/20 alle ore 22:20:53