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Titolo:
Dopamine D2 receptor dimers in human and rat brain
Autore:
Zawarynski, P; Tallerico, T; Seeman, P; Lee, SP; ODowd, BF; George, SR;
Indirizzi:
Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 macol, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 chiat, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 t Med, Toronto, ON M5S 1A8, Canada Ctr Addict & Mental Hlth, Toronto, ON M5S 2S1, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5S 2S1 to, ON M5S 2S1, Canada
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 441, anno: 1998,
pagine: 383 - 386
SICI:
0014-5793(199812)441:3<383:DDRDIH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CARDIAC MUSCARINIC RECEPTORS; NAIVE SCHIZOPHRENIC-PATIENTS; C-11 N-METHYLSPIPERONE; SF9 CELLS; D-2; AFFINITY; DENSITY; BINDING; PALMITOYLATION;
Keywords:
dopamine receptor; photoaffinity labelling; receptor dimer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Seeman, P Univonto,nto, Dept Pharmacol, Med Sci Bldg,8 Taddle Creek Rd,Room 4344, Tor Univ Toronto Med Sci Bldg,8 Taddle Creek Rd,Room 4344 Toronto ON Canada M5S 1A8
Citazione:
P. Zawarynski et al., "Dopamine D2 receptor dimers in human and rat brain", FEBS LETTER, 441(3), 1998, pp. 383-386

Abstract

In order to determine whether dimers of dopamine D2 receptors can occur inmammalian brain, rat and human brain striatal membranes were photolabelledwith two radioactive photoaffinity compounds selective for dopamine D2 receptors, [I-125]azidophenethylspiperone and [I-125]-4-azido-5-iodonemonapride, It was found that [I-125]azidophenethylspiperone only labelled the D2 monomer, while [I-125]-4-azido-5-iodonemonapride labelled both D2 monomers and dimers, despite the fact that very high concentrations (6 nM) of both radiocompounds mere used. In addition, human cloned D2 receptors were probed with a D2-specific antibody, revealing multiple bands indicating the existence of trimers, tetramers and pentamers of D2 receptors, The different D2-binding patterns of the spiperone and Benzamide congeners may explain the different densities of dopamine D2 receptors found with these two radioligandsin human brain positron tomography in health and disease. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 21:08:46