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Titolo:
Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue
Autore:
Zuo, J; Neubauer, D; Dyess, K; Ferguson, TA; Muir, D;
Indirizzi:
UnivAFlorida, Inst Brain, Dept Pediat, Div Neurol, Gainesville, FL 32610 US Univ Florida Gainesville FL USA 32610 iv Neurol, Gainesville, FL 32610 US Univ Florida, Inst Brain, Dept Neurosci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA Univ Florida, Coll Med, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Coll Med, Gainesville, FL 32610 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 154, anno: 1998,
pagine: 654 - 662
SICI:
0014-4886(199812)154:2<654:DOCSPE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EXTRACELLULAR-MATRIX MOLECULES; IN-VITRO; INHIBITORY MOLECULES; AXONAL REGENERATION; OUTGROWTH INVITRO; MAMMALIAN CNS; SCAR TISSUE; N-CAM; LAMININ;
Keywords:
chondroitin sulfate proteoglycan; laminin; neuronal regeneration; neurite inhibitor; rat spinal cord injury; cryoculture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Muir, D UnivAFlorida, Inst Brain, Dept Pediat, Div Neurol, Gainesville, FL32610 US Univ Florida Gainesville FL USA 32610 l, Gainesville, FL 32610 US
Citazione:
J. Zuo et al., "Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue", EXP NEUROL, 154(2), 1998, pp. 654-662

Abstract

The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrate. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and injured adult spinal cord tissue sections treated with chondroitinases. Neuritic growth on normal spinal cord tissue was meager. However, both the percentage of neurons with neurites and the average neurite length were substantially greater on sections treated with chondroitinaseABC. Enzymes that specifically degraded dermatan sulfate or hyaluronan were ineffective. Neuritic growth was significantly greater on injured (compared to normal) spinal cord and a further dramatic increase resulted from chondroitinase ABC treatment. Neurites grew equally within white and gray matter regions after chondroitinase treatment. Observed increases in neurite outgrowth on chondroitinase-treated tissues were largely inhibited in the presence of function-blocking laminin antibodies. These findings indicate thatinhibitory CSPG is widely distributed and predominant in both normal and injured spinal cord tissues. Additionally, inhibitory CSPG is implicated in negating the potential stimulatory effects of laminin that might otherwise support spinal cord regeneration. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:13:03