Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed tothe pretectum in adult rats
Autore:
Whiteley, SJO; Sauve, Y; Aviles-Trigueros, M; Vidal-Sanz, M; Lund, RD;
Indirizzi:
Instnglandalmol, Dept Pathol, Neural Transplant Program, London EC1V 9EL, E Inst Ophthalmol London England EC1V 9EL lant Program, London EC1V 9EL, E Univinurcia, Fac Med, Dept Oftalmol, Lab Oftalmol Expt, E-30100 Murcia, Spa Univ Murcia Murcia Spain E-30100 Lab Oftalmol Expt, E-30100 Murcia, Spa
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 154, anno: 1998,
pagine: 560 - 572
SICI:
0014-4886(199812)154:2<560:EADORP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR COLLICULUS; ALBINO-RATS; REGROWTH; RESPONSES; OLIVARY; NUCLEUS; PUPILLOCONSTRICTION; TRANSPLANTS; INHIBITORS; ANTIBODY;
Keywords:
peripheral nerve; regeneration; pupillary light reflex; retina; axons; functional recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Whiteley, SJO Harvard2114v, Sch Med, Schepens Eye Res Inst, 10 Staniford St, Boston, MA 0 Harvard Univ 10 Staniford St Boston MA USA 02114 oston, MA 0
Citazione:
S.J.O. Whiteley et al., "Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed tothe pretectum in adult rats", EXP NEUROL, 154(2), 1998, pp. 560-572

Abstract

The functional reinnervation of the olivary pretectal nucleus (OPN) was studied in adult rats with peripheral nerve (PN) grafts bridging the interrupted retinopretectal pathway. Functional recovery was assessed quantitatively using established pupillometry techniques. The effect of intravitreal tuftsin fragment 1-3 (tuftsin 1-3) injections during the grafting procedure was also studied. A total of 53 adult rats received autologous PN grafts connecting the ocular Stump of the transected optic nerve to the ipsilateral OPN. The contralateral eye was enucleated to remove the input from that eye to the OPN. A pupillary light reflex was elicited from 35 of the 53 PN-grafted animals and in the best cases, a response was obtained which compared closely to that recorded from control animals. Tuftsin 1-3 was found to increase the rate of recovery of the response. The response amplitude of PN-grafted rats was generally found to diminish with repeated stimulus presentation and also appeared to deteriorate with age. This was in contrast to control animals' responses. However, a PLR could still be elicited in 3 of the 6 animals studied 15 months after PN-grafting, These findings indicate that anear-normal PLR function can be restored using a peripheral nerve graft, but there are a number of factors that are likely to compromise optimal outcome. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:51:30