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Titolo:
The hemoglobin-deficit mouse: Cure of the anemia following bone marrow transplantation with normal marrow
Autore:
Simon-Stoos, KL; Bloom, ML;
Indirizzi:
NHLBI, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EXPERIMENTAL HEMATOLOGY
fascicolo: 1, volume: 27, anno: 1999,
pagine: 162 - 168
SICI:
0301-472X(199901)27:1<162:THMCOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS; MICE;
Keywords:
bone marrow transplantation; hemoglobin deficit; anemia; mice; congenic strains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bloom, ML NHLBI, NIH, Bldg 10,Room 7C 118, Bethesda, MD 20892 USA NHLBI Bldg 10,Room 7C 118 Bethesda MD USA 20892 da, MD 20892 USA
Citazione:
K.L. Simon-Stoos e M.L. Bloom, "The hemoglobin-deficit mouse: Cure of the anemia following bone marrow transplantation with normal marrow", EXP HEMATOL, 27(1), 1999, pp. 162-168

Abstract

The hemoglobin-deficit mouse mutant (hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-recessive manner, Previousresults from our laboratory indicated that normal mice develop anemia if they are transplanted with bone marrow from mutant animals. Furthermore, we demonstrated a delay in erythroid reconstitution from hbd marrow compared to normal marrow, Although these experiments show a defect that is intrinsicto hbd marrow, it is unclear if the hbd phenotype is solely the result of a bone marrow-derived defect. To exclude an environmental influence on hbn anemia, we attempted to cure the defect by transplanting normal marrow intothe hbd mouse. We observed that the transplanted animals converted to a normal phenotype, These results indicated that the defect is bone marrow derived, In contrast to the microcytosis mutant whose defective gene is ubiquitiously expressed, our data suggest that the defective gene product is specific to hematopoietic cells. (C) 1999 International Society for ExperimentalHematology. Published by Elsevier Science Inc.

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Documento generato il 27/05/20 alle ore 15:46:03