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Titolo:
Effects of nicotine on K+ channel currents in vascular smooth muscle cellsfrom rat tail arteries
Autore:
Tang, GH; Hanna, ST; Wang, R;
Indirizzi:
Univ Saskatchewan, Dept Physiol, Saskatoon, SK S7N 5E5, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5E5 skatoon, SK S7N 5E5, Canada
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 364, anno: 1999,
pagine: 247 - 254
SICI:
0014-2999(19990108)364:2-3<247:EONOKC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOKELESS TOBACCO; CALCIUM; INVOLVEMENT; VENTRICLE; NEURONS;
Keywords:
nicotine; patch-clamp; peripheral artery; smokeless tobacco; tetraethylammonium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, R Univadaskatchewan, Dept Physiol, 107 Wiggins Rd, Saskatoon, SK S7N5E5, Can Univ Saskatchewan 107 Wiggins Rd Saskatoon SK Canada S7N 5E5 , Can
Citazione:
G.H. Tang et al., "Effects of nicotine on K+ channel currents in vascular smooth muscle cellsfrom rat tail arteries", EUR J PHARM, 364(2-3), 1999, pp. 247-254

Abstract

Intake of nicotine has been related in many cases to acute or chronic hypertension. Using the patch-clamp technique the effect of nicotine on voltage-dependent K+ channel currents in rat tail artery smooth muscle cells was studied. Nicotine at concentrations of 1-100 mu M or 0.3-3 mM increased or decreased, respectively, the amplitude of the tetraethylammonium-sensitive K currents. Pretreatment of cells with 10 mu M dihydro-beta-erythroidine hydrobromide, a nicotinic receptor antagonist, abolished the excitatory effect (n = 6), but not the inhibitory effect (n = 10), of nicotine on K+ channel currents. The activation of nicotinic receptors with 100 mu M 1,1-dimethyl-4-phenylpiperazinium iodide increased K+ channel currents by 27.4 +/- 3.8% (n = 13, P < 0.01). Our results indicate that the excitatory and inhibitory effects of nicotine on K+ channels are respectively mediated by a nicotinic receptor-dependent mechanism and by a direct interaction of nicotine with K+ channels. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:54:41