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Titolo:
Correlation of hippocampal neuronal density and FDG-PET in mesial temporallobe epilepsy
Autore:
Foldvary, N; Lee, N; Hanson, MW; Coleman, RE; Hulette, CM; Friedman, AH; Bej, MD; Radtke, RA;
Indirizzi:
Cleveland,Clin Fdn, Dept Neurol, Sect Epilepsy & Sleep Disorders, Cleveland Cleveland Clin Fdn Cleveland OH USA 44195 sy & Sleep Disorders, Cleveland Durham VA Med Ctr, Neurodiagnost Ctr, Durham, NC USA Durham VA Med Ctr Durham NC USA d Ctr, Neurodiagnost Ctr, Durham, NC USA Duke Univ, Med Ctr, Div Neurol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 , Med Ctr, Div Neurol, Durham, NC 27710 USA Duke Univ, Med Ctr, Div Nucl Med, Durham, NC USA Duke Univ Durham NC USADuke Univ, Med Ctr, Div Nucl Med, Durham, NC USA Duke Univ, Med Ctr, Dept Neuropathol, Durham, NC USA Duke Univ Durham NC USA Univ, Med Ctr, Dept Neuropathol, Durham, NC USA Duke Univ, Med Ctr, Div Neurosurg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ed Ctr, Div Neurosurg, Durham, NC 27710 USA
Titolo Testata:
EPILEPSIA
fascicolo: 1, volume: 40, anno: 1999,
pagine: 26 - 29
SICI:
0013-9580(199901)40:1<26:COHNDA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; REGIONAL HYPOMETABOLISM; LOBECTOMY; METABOLISM; SCLEROSIS; SEIZURES; SCANS;
Keywords:
FDG-PET; mesial temporal lobe epilepsy; mesial temporal sclerosis; hippocampal neuronal density;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Foldvary, N Clevelandidlin Fdn, Dept Neurol, Sect Epilepsy & Sleep Disorders, 9500 Eucl Cleveland Clin Fdn 9500 Euclid Ave,S-51 Cleveland OH USA 44195
Citazione:
N. Foldvary et al., "Correlation of hippocampal neuronal density and FDG-PET in mesial temporallobe epilepsy", EPILEPSIA, 40(1), 1999, pp. 26-29

Abstract

Purpose: Interictal [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) reveals regional hypometabolism in 60-80% of patients with mesial temporal lobe epilepsy (MTLE). The extent of hypometabolism generally extends beyond the epileptogenic zone. The pathophysiology underlying this widespread change is unknown. This study evaluated the relation between hippocampal neuronal loss and hypometabolism in patients with MTLE,Methods: Forty-three patients with MTLE after anterior temporal lobectomy were included. Pathology demonstrated mesial temporal sclerosis (n = 41) orendfolium sclerosis (n = 2). Interictal FDG-PET scans were graded by visual analysis on a scale ranging from normal (grade 1) to severe (grade 5) hypometabolism. Neuronal counting was performed in the subiculum, hippocampal subfields, and dentate granular cell layer (DG). Neuronal density of patients was compared with that of seven autopsy controls. Data were compared by using Student's t tests and Kruskal-Wallis one-way analysis of variance (ANOVA). Results: Significant neuronal loss in CA1 through CA4 and DG was found in patients compared with controls. Neuronal density in the subiculum, CA1, CA4, and DG did nor correlate with severity of hypometabolism. However, patients with abnormal FDG-PET had higher neuronal density in CA2 and CA3 versuspatients with normal studies. Conclusions: This study supports a previous observation that degree of FDG-PET hypometabolism does not parallel severity of hippocampal neuronal lossin MTLE.

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Documento generato il 09/04/20 alle ore 07:32:21