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Titolo:
Early angiotensin converting enzyme inhibitor therapy after experimental myocardial infarction prevents left ventricular dilation by reducing infarctexpansion: a possible mechanism of clinical benefits
Autore:
Ali, SM; Brown, EJ; Nallapati, SR; Alhaddad, IA;
Indirizzi:
Bronx Lebanon Hosp Ctr, Dept Med, Div Cardiol, Bronx, NY 10457 USA Bronx Lebanon Hosp Ctr Bronx NY USA 10457 iv Cardiol, Bronx, NY 10457 USA
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 12, volume: 9, anno: 1998,
pagine: 815 - 821
SICI:
0954-6928(1998)9:12<815:EACEIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; CAPTOPRIL; RAT; DYSFUNCTION; TRIAL; SIZE; DILATATION; SURVIVAL; LIMITATION; MORTALITY;
Keywords:
myocardial infarction; infarct expansion; left ventricular remodeling; left ventricular dilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Alhaddad, IA Bronx Lebanon Hosp Ctr, Dept Med, Div Cardiol, 1650 Grand Concourse, Bronx, Bronx Lebanon Hosp Ctr 1650 Grand Concourse Bronx NY USA 10457
Citazione:
S.M. Ali et al., "Early angiotensin converting enzyme inhibitor therapy after experimental myocardial infarction prevents left ventricular dilation by reducing infarctexpansion: a possible mechanism of clinical benefits", CORON ART D, 9(12), 1998, pp. 815-821

Abstract

Objective To examine the effects of early angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction on infarct expansion in an experimental rat model. Background ACE inhibitor therapy within 24 h of acute myocardial infarction (AMI) reduces mortality by unknown mechanism(s). Methods Rats underwent permanent coronary artery occlusion. A treated group received enalapril (1.9 +/- 0.2 mg/kg) daily in drinking water beginning 2 h after coronary artery occlusion, a time too late to reduce infarct size. Rats were sacrificed 2 days or 2 weeks after myocardial infarction. Hearts were arrested and fixed at a constant pressure, then sectioned and photographed for morphometric analysis. Results Infarcts in the control group expanded between 2 days and 2 weeks after myocardial infarction (expansion index 0.7 +/- 0.1 versus 2.5 +/- 0.4, P < 0.05). However, infarct expansion remained unchanged in the enalaprilgroup between 2 days and 2 weeks after myocardial infarction (expansion index 0.8 +/- 0.1 versus 1.3 +/- 0.1, NS). Two weeks after myocardial infarction, the enalapril group had fewer expanded infarcts than the control group(expansion index 1.3 +/- 0.1 versus 2.5 +/- 0.4, P < 0.05). While left ventricular volume increased in the control group between 2 days and 2 weeks after myocardial infarction (0.17 +/- 0.01 ml versus 0.36 +/- 0.03 ml, P < 0.05), it remained constant in the enalapril group (0.22 +/- 0.02 ml versus 0.25 +/- 0.03 ml, NS). Two weeks after myocardial infarction, the left ventricles were larger in the control group than in the enalapril group (0.36 +/- 0.03 ml versus 0.25 +/- 0.03 ml, P < 0.05). Conclusions Treatment with enalapril initiated 2 h after AMI prevented left ventricular dilation by limiting infarct expansion. This may explain the mechanism by which ACE inhibitor therapy started within 24 h of an AMI improves survival 5-6 weeks after infarction. Coronary Artery Dis 9:815-821 (C)1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:44:48