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Titolo:
Overexpression of ornithine decarboxylase in prostate cancer and prostaticfluid in humans
Autore:
Mohan, RR; Challa, A; Gupta, S; Bostwick, DG; Ahmad, N; Agarwal, R; Marengo, SR; Amini, SB; Paras, F; MacLennan, GT; Resnick, MI; Mukhtar, H;
Indirizzi:
Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Urol, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA CaseAWestern Reserve Univ, Dept Biostat & Epidemiol, Cleveland, OH 44106 US Case Western Reserve Univ Cleveland OH USA 44106 , Cleveland, OH 44106 US Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 1, volume: 5, anno: 1999,
pagine: 143 - 147
SICI:
1078-0432(199901)5:1<143:OOODIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-DIFLUOROMETHYLORNITHINE; MOUSE EPIDERMIS; TUMOR PROMOTION; GROWTH; EXPRESSION; INDUCTION; CARCINOMA; CELLS; SKIN; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mukhtar, H Case4106tern Reserve Univ, Dept Dermatol, 11100 Euclid Ave, Cleveland, OH 4 Case Western Reserve Univ 11100 Euclid Ave Cleveland OH USA 44106
Citazione:
R.R. Mohan et al., "Overexpression of ornithine decarboxylase in prostate cancer and prostaticfluid in humans", CLIN CANC R, 5(1), 1999, pp. 143-147

Abstract

Prostate cancer (PCA), the most commonly diagnosed cancer in males in the United States, is the second leading cause of cancer-related deaths of males in this country. Because of the poor success rate in the treatment of PCA, an intervention at an early stage may reduce the progression of small carcinoma to large metastatic lesion, thereby reducing PCA-related deaths. Concerted efforts are needed to establish mechanism-based approaches to develop: (a) the markers for early detection of the disease as well as toward monitoring the efficacy of treatment(s); and (b) novel chemopreventive strategies against PCA. Using unique samples of pair-matched benign and cancer tissue obtained from the same PCA patient, we showed that ornithine decarboxylase (ODC) activity is significantly (P < 0.001) elevated in PCA (1142 +/- 100; mean +/- SE) than in paired benign tissue (427 +/- 51; mean +/- SE). The immunoblot analysis also showed a significant elevation in the protein expression of ODC in the PCA tissues as compared with the paired benign tissue. Furthermore, our data showed that the ODC activity in the prostatic fluid obtained by a digital rectal massage from the patients with PCA (3847 +/-162; mean +/- SE) was significantly higher than in the patients with benign prostatic hyperplasia (2742 +/- 167; mean +/- SE) or normal individuals (1244 +/- 67; mean +/- SE). This observation might be of significance because the prostatic fluid could be obtained noninvasively by digital rectal massage. We suggest that ODC could serve as a target for early detection of human PCA as well as for monitoring the efficacy of treatment(s). The development of ODC as a target for novel chemopreventive strategies against PCA isan intriguing possibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:59:46