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Titolo:
Differential regulation of peroxisome proliferator activated receptor gamma 1 (PPAR gamma 1) and PPAR gamma 2 messenger RNA expression in the early stages of adipogenesis
Autore:
Saladin, R; Fajas, L; Dana, S; Halvorsen, YD; Auwerx, J; Briggs, M;
Indirizzi:
Ligand Pharmaceut Inc, San Diego, CA 92121 USA Ligand Pharmaceut Inc San Diego CA USA 92121 Inc, San Diego, CA 92121 USA Inst Pasteur, INSERM U325, F-59019 Lille, France Inst Pasteur Lille France F-59019 ur, INSERM U325, F-59019 Lille, France Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France Zen Bio Inc, Res Triangle Pk, NC 27709 USA Zen Bio Inc Res Triangle Pk NCUSA 27709 c, Res Triangle Pk, NC 27709 USA
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 1, volume: 10, anno: 1999,
pagine: 43 - 48
SICI:
1044-9523(199901)10:1<43:DROPPA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; GENE-EXPRESSION; PPAR-GAMMA; ADIPOCYTE DIFFERENTIATION; TISSUE DISTRIBUTION; ECTOPIC EXPRESSION; INSULIN; ISOFORMS; CELLS; PROMOTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Saladin, R Ligand Pharmaceut Inc, 10255 Sci Ctr Dr, San Diego, CA 92121 USA Ligand Pharmaceut Inc 10255 Sci Ctr Dr San Diego CA USA 92121 A
Citazione:
R. Saladin et al., "Differential regulation of peroxisome proliferator activated receptor gamma 1 (PPAR gamma 1) and PPAR gamma 2 messenger RNA expression in the early stages of adipogenesis", CELL GROWTH, 10(1), 1999, pp. 43-48

Abstract

Adipocyte differentiation is driven by the expression and activation of three transcription factor families: the differentially expressed CAAT/enhancer binding proteins (C/EBPs) alpha, beta, and delta; the helix-loop-helix adipocyte differentiation and determination factor-1; and peroxisome proliferator activated receptor gamma (PPAR gamma), expressed as two isoforms, PPAR gamma 1 and the adipocyte-specific PPAR gamma 2, Overexpression of PPAR gamma can induce adipocyte differentiation; therefore, we analyzed the expression of the two PPAR gamma isoforms during early stages of differentiationto determine whether one was preferentially induced as an early determining event, Surprisingly, in the first 24 h, a 3-6-fold increase of PPAR gamma2 mRNA was observed, whereas PPAR gamma 1 mRNA remained unchanged. PPAR gamma 1 was induced 1 day later. Overexpression of C/EBP beta has also been shown to induce adipocyte differentiation. A C/EBP site was identified only in the human PPAR gamma 2 promoter. Its deletion blunted the response of PPAR gamma 2 promoter to cotransfected C/EBP beta or methylisobutylxanthine treatment. We hypothesize that PPAR gamma 2 initiates adipocyte differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:37:09