Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CD44 variants but not CD44s cooperate with beta 1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
Autore:
Katagiri, YU; Sleeman, J; Fujii, H; Herrlich, P; Hotta, H; Tanaka, K; Chikuma, S; Yagita, H; Okumura, K; Murakami, M; Saiki, I; Chambers, AF; Uede, T;
Indirizzi:
Hokkaido Univ, Inst Immunol Sci, Sect Immunopathogenesis, Kita Ku, Sapporo, Hokkaido Univ Sapporo Hokkaido Japan 0600815 hogenesis, Kita Ku, Sapporo, Forschungszentrum Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany Forschungszentrum Karlsruhe Karlsruhe Germany D-76021 Karlsruhe, Germany Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Toyama Med & Pharmaceut Univ Toyama Japan 9300194 dit Sino Japanese Med, Juntendo Univ, Sch Med, Dept Immunol, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ed, Dept Immunol, Tokyo 1138421, Japan London Reg Canc Ctr, Dept Oncol, Div Expt Oncol, London, ON N6A 4L6, Canada London Reg Canc Ctr London ON Canada N6A 4L6 , London, ON N6A 4L6, Canada
Titolo Testata:
CANCER RESEARCH
fascicolo: 1, volume: 59, anno: 1999,
pagine: 219 - 226
SICI:
0008-5472(19990101)59:1<219:CVBNCC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-V INTEGRINS; METASTATIC BEHAVIOR; HYALURONAN-BINDING; CARCINOMA-CELLS; SPLICE VARIANTS; ADHESION; PROTEINS; GLYCOPROTEIN; FIBRONECTIN; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Uede, T HokkaidoNishi, Inst Immunol Sci, Sect Immunopathogenesis, Kita Ku,Kita 15, Hokkaido Univ Kita 15,Nishi 7 Sapporo Hokkaido Japan 0600815 a 15,
Citazione:
Y.U. Katagiri et al., "CD44 variants but not CD44s cooperate with beta 1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis", CANCER RES, 59(1), 1999, pp. 219-226

Abstract

The expression of osteopontin (OPN), CD44 variants, and integrins has beencorrelated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility, First, we demonstrate that severaldifferent CD44 variants bind to OPN in an arginine-glycine-aspartic acid-independent manner, but that the standard form of CD44 does not. These CD44 variants bind to both the amino- and COOH-terminal portions of OPN independently of the arginine-glycine-aspartic acid sequence, suggesting that multiple domains on OPN can be bound by the CD44 variants, Antibodies directed against the integrin beta 1 subunit are able to inhibit this binding. The binding of CD44 variants to OPN is significantly augmented by both anti-CD44sand anti-CD44v antibodies, This augmentation by anti-CD44 antibodies is OPN specific and, again, can be blocked by anti-beta 1 antibodies. Finally, we show that OPN binding by CD44 variants/beta 1-containing integrins promotes cell spreading, motility, and chemotactic behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:53:15